Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epirubicin
Drug ID BADD_D00784
Description An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
Indications and Usage For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.
Marketing Status Prescription; Discontinued
ATC Code L01DB03
DrugBank ID DB00445
KEGG ID D07901
MeSH ID D015251
PubChem ID 41867
TTD Drug ID D0C9XJ
NDC Product Code Not Available
Synonyms Epirubicin | 4'-Epidoxorubicin | 4' Epidoxorubicin | 4'-Epi-Doxorubicin | 4' Epi Doxorubicin | 4'-Epi-Adriamycin | 4' Epi Adriamycin | 4'-Epiadriamycin | 4' Epiadriamycin | 4'-Epi-DXR | 4' Epi DXR | EPI-cell | EPI cell | EPIcell | Epilem | Farmorubicina | IMI-28 | IMI 28 | IMI28 | NSC-256942 | NSC 256942 | NSC256942 | Ellence | Pharmorubicin | Farmorubicine | Farmorubicin | Epirubicin Hydrochloride | Hydrochloride, Epirubicin
Chemical Information
Molecular Formula C27H29NO11
CAS Registry Number 56420-45-2
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ejection fraction decreased13.14.02.003--
Lymphatic disorder01.09.01.003--Not Available
Transaminases increased13.03.01.015--Not Available
Haemorrhage24.07.01.002--Not Available
Chemical cystitis20.03.01.004; 12.03.02.001--Not Available
Ventricular dysfunction02.04.02.005--Not Available
Angiopathy24.03.02.007--Not Available
Urine output13.13.03.003--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Recall phenomenon23.03.07.005; 12.02.06.001--
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.01.01.003--Not Available
Embolism24.01.01.009--
Infestation23.09.05.001; 11.09.01.001--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Neoplasm progression16.16.02.0050.000139%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Ill-defined disorder08.01.03.049--Not Available
Polyp08.01.06.010; 16.02.02.005--Not Available
Blood disorder01.05.01.004--Not Available
Disease progression08.01.03.0380.000486%
Bone marrow failure01.03.03.0050.002931%
Hypertransaminasaemia09.01.02.0050.000533%Not Available
Acute kidney injury20.01.03.016--
Multiple organ dysfunction syndrome08.01.03.057--
Maternal drugs affecting foetus12.03.03.006; 18.03.03.0090.001598%Not Available
Staphylococcus test positive13.08.01.0150.000533%Not Available
Klebsiella test positive13.08.01.0110.000533%Not Available
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