Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epirubicin
Drug ID BADD_D00784
Description An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
Indications and Usage For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.
Marketing Status approved
ATC Code L01DB03
DrugBank ID DB00445
KEGG ID D07901
MeSH ID D015251
PubChem ID 41867
TTD Drug ID D0C9XJ
NDC Product Code Not Available
UNII 3Z8479ZZ5X
Synonyms Epirubicin | 4'-Epidoxorubicin | 4' Epidoxorubicin | 4'-Epi-Doxorubicin | 4' Epi Doxorubicin | 4'-Epi-Adriamycin | 4' Epi Adriamycin | 4'-Epiadriamycin | 4' Epiadriamycin | 4'-Epi-DXR | 4' Epi DXR | EPI-cell | EPI cell | EPIcell | Epilem | Farmorubicina | IMI-28 | IMI 28 | IMI28 | NSC-256942 | NSC 256942 | NSC256942 | Ellence | Pharmorubicin | Farmorubicine | Farmorubicin | Epirubicin Hydrochloride | Hydrochloride, Epirubicin
Chemical Information
Molecular Formula C27H29NO11
CAS Registry Number 56420-45-2
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Menopausal symptoms21.02.02.002--Not Available
Metastases to liver16.22.02.001; 09.04.02.0040.000112%Not Available
Migraine24.03.05.003; 17.14.02.0010.000112%Not Available
Mucosal inflammation08.01.06.0020.000168%Not Available
Myelodysplastic syndrome01.10.04.001; 16.01.04.001--
Myocarditis02.04.03.001--
Nausea07.01.07.0010.000672%
Necrosis24.04.02.006; 08.03.03.001--Not Available
Neuropathy peripheral17.09.03.0030.000112%Not Available
Neutropenia01.02.03.0040.000951%Not Available
Odynophagia07.01.06.0360.000168%Not Available
Oesophagitis07.08.05.001--
Pain08.01.08.004--
Pain in jaw15.02.01.0030.000246%Not Available
Palpitations02.11.04.0120.000112%
Pancytopenia01.03.03.0030.000112%Not Available
Paraesthesia23.03.03.094; 17.02.06.005--
Pericardial effusion02.06.01.002--
Pericarditis02.06.02.001--
Phlebitis24.12.03.004; 12.02.01.002--
Photosensitivity reaction23.03.09.003--
Pleural effusion22.05.02.0020.000168%
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pollakiuria20.02.02.007--
Premature baby18.04.02.0010.000112%Not Available
Premature menopause21.02.02.004; 05.05.01.016--
Pruritus23.03.12.001--
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary oedema22.01.03.003; 02.05.02.003--
Pyrexia08.05.02.0030.000672%
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ADReCS-Target
Drug Name ADR Term Target
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