Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Entecavir
Drug ID BADD_D00774
Description Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS). Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). It was approved by the U.S. Food and Drug Administration (FDA) in March 2005.
Indications and Usage For the treatment of chronic hepatitis B virus infection in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
Marketing Status Prescription
ATC Code J05AF10
DrugBank ID DB00442
KEGG ID D04008
MeSH ID C413685
PubChem ID 135398508
TTD Drug ID D0KR2J
NDC Product Code 42291-261; 31722-833; 69097-425; 60050-057; 43547-437; 16729-389; 60687-216; 51991-895; 42291-262; 0003-1614; 42806-659; 65862-842; 50268-289; 71921-194; 0003-1611; 63285-888; 63285-887; 68382-921; 65862-798; 70771-1020; 42806-658; 51407-065; 51991-896; 16714-718; 68382-920; 16729-388; 71921-195; 62227-101; 53104-7692; 31722-834; 16714-717; 65862-841; 0003-1612; 13612-0020; 70771-1019; 65977-0086; 62227-102; 69097-426; 51407-064; 17381-031; 66406-0331; 60050-077; 76397-001; 65162-446; 65162-449; 43547-436
Synonyms entecavir | Baraclude
Chemical Information
Molecular Formula C12H15N5O3
CAS Registry Number 142217-69-4
SMILES C=C1C(CC(C1CO)O)N2C=NC3=C2N=C(NC3=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Feeding disorder19.09.01.003; 14.03.02.0030.014982%Not Available
Lung infection22.07.01.008; 11.01.09.0080.014982%
Malnutrition14.03.02.004--Not Available
Mental disorder19.07.01.0020.022473%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Blood disorder01.05.01.004--Not Available
Immunodeficiency10.03.02.002--Not Available
Hepatobiliary disease09.01.08.003--Not Available
Renal impairment20.01.03.0100.209749%Not Available
Chronic kidney disease20.01.03.0170.014982%
Bone marrow failure01.03.03.0050.014982%
Renal cell carcinoma20.01.04.003; 16.08.02.0020.005863%Not Available
Oropharyngeal pain07.05.05.004; 22.02.05.0220.022473%
Product taste abnormal27.02.02.001--Not Available
Acute kidney injury20.01.03.0160.052437%
Rheumatic disorder15.03.04.018; 10.02.01.0480.022473%Not Available
Hepatic cancer16.07.02.004; 09.04.02.0080.078167%Not Available
Hepatocellular carcinoma09.04.02.010; 16.07.02.0050.052763%Not Available
Lung adenocarcinoma22.08.01.007; 16.19.01.0020.005863%Not Available
Neonatal respiratory distress syndrome22.11.02.010; 18.04.10.0030.014982%Not Available
Normal newborn18.08.06.0010.022473%Not Available
Cardiac perforation12.02.01.020; 02.01.01.0140.014982%Not Available
Viral load increased13.08.03.0350.044946%Not Available
Metastatic gastric cancer16.13.03.004; 07.21.02.0040.003908%Not Available
Virologic failure08.06.01.034; 11.01.08.0620.022473%Not Available
Hepatitis B DNA increased13.08.03.0190.059928%Not Available
Foetal hypokinesia18.03.02.0150.022473%Not Available
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