Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Enflurane
Drug ID BADD_D00770
Description Enflurane is a halogenated inhalational anesthetic initially approved by the FDA in 1972. Since this date, it has been withdrawn from the US market.[L13646,L13649] Unlike its other inhalational anesthetic counterparts including [isoflurane] and [halothane], enflurane is known to induce seizure activity. In addition, it is known to cause increased cardio depressant effects when compared to other inhaled anesthetics.[A202022]
Indications and Usage Used for the induction and maintenance of general anaesthesia during surgery and cesarean section and also used for analgesia during vaginal delivery.
Marketing Status Discontinued
ATC Code N01AB04
DrugBank ID DB00228
KEGG ID D00543
MeSH ID D004737
PubChem ID 3226
TTD Drug ID D0AO9S
NDC Product Code Not Available
Synonyms Enflurane | Etran | Enlirane | Ethrane | Alyrane | Enfran
Chemical Information
Molecular Formula CHF2OCF2CHClF
CAS Registry Number 13838-16-9
SMILES C(C(OC(F)F)(F)F)(F)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaesthesia17.02.07.002--Not Available
Arrhythmia02.03.02.001--Not Available
Body temperature increased13.15.01.001--Not Available
Carbon dioxide decreased13.02.01.012--Not Available
Chills15.05.03.016; 08.01.09.001--
Hepatic failure09.01.03.002--
Hepatic necrosis09.01.07.002--
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hyperkalaemia14.05.03.001--
Hyperthermia malignant08.05.01.002--Not Available
Hypocapnia22.02.02.008--Not Available
Hypotension24.06.03.002--
Hypoxia22.02.02.003--
Injury12.01.08.004--Not Available
Nausea07.01.07.001--
Psychomotor hyperactivity19.11.02.003; 17.01.02.011--Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Seizure17.12.03.001--
Vomiting07.01.07.003--
White blood cell count increased13.01.06.013--Not Available
Transaminases increased13.03.01.015--Not Available
Pulmonary function test decreased13.19.01.001--Not Available
Liver injury09.01.07.022; 12.01.02.003--Not Available
Traumatic liver injury12.01.02.008; 09.01.08.010--Not Available
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