Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Emtricitabine
Drug ID BADD_D00766
Description Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection in high risk adolescents and adults.[L9010] Emtricitabine is a cytidine analogue.[L9019] The drug works by inhibiting HIV reverse transcriptase, preventing transcription of HIV RNA to DNA.[L9019] Emtricitabine was granted FDA approval on 2 July 2003.[L9019]
Indications and Usage Indicated, in combination with other antiretroviral agents, for the treatment of HIV-1 infection in adults and for postexposure prophylaxis of HIV infection in health care workers and others exposed occupationally or nonoccupationally via percutaneous injury or mucous membrane or nonintact skin contact with blood, tissues, or other body fluids associated with risk for transmission of the virus.
Marketing Status Prescription
ATC Code J05AF09
DrugBank ID DB00879
KEGG ID D01199
MeSH ID D000068679
PubChem ID 60877
TTD Drug ID D0S9SD
NDC Product Code 68554-0064; 70518-1847; 59997-0005; 42385-304; 72761-008; 69097-642; 52696-0008; 65862-305; 70518-2906; 42385-710; 49711-1516; 61958-0601; 69037-0003; 66721-400; 65015-838; 33342-500; 53104-7637; 68554-0027; 70966-0024; 65015-827; 61958-0602; 65015-883; 66406-0209
Synonyms Emtricitabine | Beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine | Beta L 2',3' dideoxy 5 fluoro 3' thiacytidine | Coviracil | Emtriva
Chemical Information
Molecular Formula C8H10FN3O3S
CAS Registry Number 143491-57-0
SMILES C1C(OC(S1)CO)N2C=C(C(=NC2=O)N)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Death08.04.01.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspepsia07.01.02.001--
Dyspnoea02.01.03.002; 22.02.01.004--
Eosinophilia01.02.04.0010.012832%
Fanconi syndrome20.05.03.009; 14.01.01.011; 03.06.01.0010.008555%Not Available
Fatigue08.01.01.002--
Fracture15.08.02.001; 12.04.02.001--
Gamma-glutamyltransferase increased13.03.01.011--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Genital ulceration23.07.03.004; 21.10.05.001--Not Available
Glomerular filtration rate decreased13.13.01.0090.017109%Not Available
Glycosuria20.02.01.005--
Haematuria20.02.01.006; 24.07.01.047--
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Headache17.14.01.001--
Heart disease congenital02.01.01.009; 03.07.07.0010.002232%Not Available
Hepatic steatosis09.01.07.003; 14.08.04.005--Not Available
Hepatitis09.01.07.004--Not Available
Hepatitis B11.05.06.002; 09.01.09.003--
Hepatomegaly09.01.05.001--Not Available
HIV infection11.05.17.002; 10.03.03.0020.034218%Not Available
Hodgkin's disease16.31.01.001; 01.16.01.0010.002232%Not Available
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