Pharmaceutical Information |
Drug Name |
Eluxadoline |
Drug ID |
BADD_D00761 |
Description |
Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system and peripherally in the gastrointestinal system. Agonism of peripheral mu-opioid receptors results in reduced colonic motility, while antagonism of central delta-opioid receptors results in improved analgesia, making eluxadoline usable for the symptoms of both pain and diarrhea characteristic of IBS-D.
Marketed under the tradename Viberzi (FDA), eluxadoline is an antimotility agent that decreases bowel contractions, inhibits colonic transit, and reduces fluid/ion secretion resulting in improved symptoms of abdominal pain and reductions in the Bristol Stool Scale. |
Indications and Usage |
For the treatment of irritable bowel syndrome with diarrhea (IBS-D). |
Marketing Status |
Prescription |
ATC Code |
A07DA06 |
DrugBank ID |
DB09272
|
KEGG ID |
D10403
|
MeSH ID |
C583636
|
PubChem ID |
11250029
|
TTD Drug ID |
D09ZXR
|
NDC Product Code |
69766-020; 59651-330; 61874-075; 61874-100; 69037-0042 |
Synonyms |
eluxadoline | Viberzi |
|
Chemical Information |
Molecular Formula |
C32H35N5O5 |
CAS Registry Number |
864821-90-9 |
SMILES |
CC1=CC(=CC(=C1CC(C(=O)N(CC2=CC(=C(C=C2)OC)C(=O)O)C(C)C3=NC=C(N3)C4=CC=CC=C4)N)C)
C(=O)N |
Chemical Structure |
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ADR Related Proteins Induced by Drug |
ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
Not Available | Not Available | Not Available | Not Available | Not Available |
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ADRs Induced by Drug |
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