Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Eltrombopag
Drug ID BADD_D00759
Description Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.
Indications and Usage Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction.
Marketing Status Prescription
ATC Code B02BX05
DrugBank ID DB06210
KEGG ID D03978
MeSH ID C520809
PubChem ID 135449332
TTD Drug ID D00PEH
NDC Product Code 47621-307
Synonyms eltrombopag | Revolade | SB-497 115 | Promacta
Chemical Information
Molecular Formula C25H22N4O4
CAS Registry Number 496775-61-2
SMILES CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neck pain15.03.04.0090.001634%
Neoplasm malignant16.16.01.0010.000852%Not Available
Nephrolithiasis20.04.01.0020.003812%
Nervousness19.06.02.003--Not Available
Neutropenia01.02.03.004--Not Available
Neutrophil count decreased13.01.06.0100.002178%
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.011--
Oral mucosal blistering07.05.05.0170.001089%Not Available
Oral pain07.05.03.0020.001089%
Pain08.01.08.004--
Pain in extremity15.03.04.0100.013069%
Pallor23.03.03.031; 24.03.04.001; 08.01.03.0320.001089%Not Available
Pancreatitis07.18.01.0010.002723%
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.0020.002178%Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.0040.001634%
Plasma cell myeloma16.23.02.004; 01.14.02.004--Not Available
Platelet count abnormal13.01.04.0050.007079%Not Available
Platelet count decreased13.01.04.0010.098562%
Platelet disorder01.08.03.0010.007624%Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumonia aspiration22.01.01.005--Not Available
Pollakiuria20.02.02.0070.002178%
Polyuria20.02.03.0020.001089%Not Available
Portal vein thrombosis24.01.03.003; 09.01.06.0070.003267%
Premature baby18.04.02.001--Not Available
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