Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Eltrombopag
Drug ID BADD_D00759
Description Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelets in the blood. Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.
Indications and Usage Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction.
Marketing Status Prescription
ATC Code B02BX05
DrugBank ID DB06210
KEGG ID D03978
MeSH ID C520809
PubChem ID 135449332
TTD Drug ID D00PEH
NDC Product Code 47621-307
Synonyms eltrombopag | Revolade | SB-497 115 | Promacta
Chemical Information
Molecular Formula C25H22N4O4
CAS Registry Number 496775-61-2
SMILES CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ill-defined disorder08.01.03.0490.001634%Not Available
Blood disorder01.05.01.0040.001089%Not Available
Respiratory syncytial virus infection22.07.02.002; 11.05.13.0010.001089%Not Available
Disease progression08.01.03.0380.002699%
Drug intolerance08.06.01.013--Not Available
Psychotic disorder19.03.01.002--
Hepatobiliary disease09.01.08.003--Not Available
Investigation13.18.01.0040.001089%Not Available
Sinus disorder22.04.06.0020.001089%
Respiratory tract infection11.01.08.017; 22.07.07.0010.001089%Not Available
Unevaluable event08.01.03.051--Not Available
Blood count abnormal13.01.07.0010.003267%Not Available
Bone marrow failure01.03.03.005--
Haematological malignancy16.21.01.002; 01.13.01.0030.000426%Not Available
Treatment failure08.06.01.017--Not Available
Oral disorder07.05.01.0050.001089%Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.004--
Acute kidney injury20.01.03.016--
Bone marrow reticulin fibrosis16.32.03.010; 01.05.01.0090.002723%Not Available
Immune thrombocytopenic purpura10.04.01.008; 01.08.01.0070.001421%Not Available
Liver function test increased13.03.01.0440.005445%Not Available
Antiphospholipid syndrome24.01.01.029; 18.02.04.002; 10.04.01.009; 01.01.02.0160.001089%Not Available
Concomitant disease aggravated08.01.03.0630.001089%Not Available
Full blood count decreased13.01.07.0040.003812%Not Available
Internal haemorrhage24.07.01.0720.001089%Not Available
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