| Drug Name |
Droxidopa |
| Drug ID |
BADD_D00732 |
| Description |
Droxidopa is a precursor of noradrenaline that is used in the treatment of Parkinsonism. It is approved for use in Japan and is currently in trials in the U.S. The racaemic form (dl-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a deficit of noradrenaline as well as of dopamine in Parkinson's disease and it has been proposed that this underlies the sudden transient freezing seen usually in advanced disease.
Though L-DOPS has been used in Japan and Southeast Asia already for some time, it is also currently in clinical trials at the phase III point in the United States (U.S.), Canada, Australia, and throughout Europe. Provided L-DOPS successfully completes clinical trials, it could be approved for the treatment of neurogenic orthostatic hypotension (NOH) as early as 2011. Additionally, phase II clinical trials for intradialytic hypotension are also underway. Chelsea Therapeutics obtained orphan drug status (ODS) for L-DOPS in the U.S. for NOH, and that of which associated with Parkinson's disease , pure autonomic failure, and multiple system atrophy, and is the pharmaceutical company developing it in that country. |
| Indications and Usage |
Droxidopa crosses the blood-brain barrier where it is converted to norepinephrine via decarboxylation by L-aromatic-amino-acid decarboxylase. Increased levels of norepinephrine in the central nervous system (CNS) may be beneficial to patients in a wide range of indications. Norephinephrine acts at alpha-adrenergic receptors as a vasoconstrictor and at beta-adrenergic receptors as a heart stimulator and artery dilator. |
| Marketing Status |
Prescription |
| ATC Code |
C01CA27 |
| DrugBank ID |
DB06262
|
| KEGG ID |
D01277
|
| MeSH ID |
D015103
|
| PubChem ID |
92974
|
| TTD Drug ID |
D0I3RO
|
| NDC Product Code |
67386-822; 70771-1611; 38217-0030; 31722-010; 68180-988; 27808-199; 69539-089; 70771-1610; 27241-200; 27241-201; 67877-704; 69539-146; 67386-820; 76278-1120; 69766-032; 59651-377; 69539-088; 67386-821; 69452-257; 31722-015; 53069-1060; 70436-140; 72205-073; 70710-1390; 58159-049; 68180-987; 0832-0720; 0832-0721; 70710-1391; 50228-429; 70710-1389; 63304-104; 70436-141; 70771-1609; 67877-705; 68180-989; 27808-201; 63304-086; 50228-431; 27808-200; 72205-072; 59651-376; 69452-256; 0054-0532; 0832-0722; 0054-0533; 59651-375; 63304-112; 72205-074; 50228-430; 27241-199; 67877-706; 42973-237; 0054-0534; 70436-142; 31722-014; 69452-258 |
| Synonyms |
Droxidopa | threo-DOPS | threo DOPS | 3,4-threo-DOPS | 3,4 threo DOPS | DL-threo-3,4-Dihydroxyphenylserine | DL threo 3,4 Dihydroxyphenylserine | erythro-3,4-Dihydroxyphenylserine | erythro 3,4 Dihydroxyphenylserine | Droxidopa, (DL-Tyr)-Isomer | 3,4-Dihydroxyphenylserine | 3,4 Dihydroxyphenylserine |
