Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Disulfiram
Drug ID BADD_D00695
Description A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Indications and Usage For the treatment and management of chronic alcoholism
Marketing Status Prescription; Discontinued
ATC Code N07BB01; P03AA04
DrugBank ID DB00822
KEGG ID D00131
MeSH ID D004221
PubChem ID 3117
TTD Drug ID D0X5SD
NDC Product Code 64980-172; 65571-0005; 0054-0356; 62135-431; 51927-3121; 42794-028; 60429-196; 62135-432; 42973-137; 72643-028; 38779-1971; 71052-221; 0054-0357; 51927-0188; 73309-150; 64980-171; 47781-607
Synonyms Disulfiram | Bis(diethylthiocarbamoyl) Disulfide | Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2 | Tetraethylthiuram Disulfide | Disulfide, Tetraethylthiuram | Antabus | Antabuse | Teturam | Dicupral | Esperal | Alcophobin | Anticol
Chemical Information
Molecular Formula C10H20N2S4
CAS Registry Number 97-77-8
SMILES CCN(CC)C(=S)SSC(=S)N(CC)CC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Brain injuryDopamine beta-hydroxylaseP09172T749372742552; 681921; 7416268; 2224697; 1503145; 476222; 9072070; 881586; 11938582; 345861; 6732388; 3537906; 8947325; 15709459
DyspnoeasAldehyde dehydrogenase family 1 member A3P47895Not Available3761172; 6368395; 12209194; 11803702; 4043765; 12724782; 6391543; 7141984; 1685418
Motor dysfunctionAldehyde dehydrogenase family 1 member A3P47895Not Available3761172; 6368395; 12209194; 11803702; 4043765; 12724782; 6391543; 7141984; 1685418
SedationAldehyde dehydrogenase family 1 member A3P47895Not Available3761172; 6368395; 12209194; 11803702; 4043765; 12724782; 6391543; 7141984; 1685418
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypomania19.16.02.0010.017310%Not Available
Hypotension24.06.03.0020.025965%
Insomnia19.02.01.002; 17.15.03.0020.017310%
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.017310%
Malaise08.01.01.0030.017310%
Metabolic acidosis14.01.01.0030.025965%Not Available
Nausea07.01.07.0010.051930%
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.0030.017310%Not Available
Neurotoxicity17.02.10.002; 12.03.01.0110.034620%Not Available
Optic neuritis17.04.05.001; 10.04.10.002; 06.04.08.002--Not Available
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Peripheral sensory neuropathy17.09.03.0050.017310%
Polyneuropathy17.09.03.012--Not Available
Rash23.03.13.0010.025965%Not Available
Seizure17.12.03.0010.017310%
Sensory loss17.02.07.007--Not Available
Somnolence17.02.04.006; 19.02.05.0030.017310%
Stress19.06.02.004--Not Available
Suicide attempt19.12.01.0040.025965%
Tenderness08.01.08.005--Not Available
Toxic encephalopathy17.13.01.004; 12.03.01.0270.069240%Not Available
Vomiting07.01.07.0030.051930%
Mental status changes19.07.01.0010.017310%Not Available
Peripheral sensorimotor neuropathy17.09.03.009--Not Available
Mental disorder19.07.01.0020.017310%Not Available
Erectile dysfunction21.03.01.007; 19.08.04.001--
Psychotic disorder19.03.01.0020.095204%
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