Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dimethyl fumarate
Drug ID BADD_D00680
Description Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.
Indications and Usage Used in multiple sclerosis patients with relapsing forms.
Marketing Status Prescription
ATC Code L04AX07
DrugBank ID DB08908
KEGG ID D03846
MeSH ID D000069462
PubChem ID 637568
TTD Drug ID D0A7MY
NDC Product Code 64406-007; 68180-776; 63759-0027; 68180-777; 69097-322; 59651-061; 70710-1205; 43598-429; 51407-441; 69238-1318; 82245-0105; 62207-003; 16729-416; 31722-657; 67877-555; 69238-1626; 43598-430; 58159-013; 69539-043; 16729-417; 31722-658; 54864-663; 64406-006; 55111-975; 70710-1416; 69238-1319; 71348-100; 10920-598; 65015-844; 0093-9218; 59285-003; 62512-0074; 62579-301; 50379-0013; 24979-127; 24979-129; 76055-0026; 70771-1532; 71348-101; 69037-0012; 55111-997; 24979-128; 64406-005; 69097-323; 69667-1229; 69539-240; 70710-1204; 0093-9219; 31722-680; 69539-042; 49812-0255; 0378-0396; 66577-043; 69097-552; 68180-778; 70771-1531; 70771-1530; 0378-0399; 51407-442; 50090-5288; 62675-0393; 67877-556; 66039-901; 67877-557; 62756-178; 71348-102
Synonyms Dimethyl Fumarate | Fumarate, Dimethyl | 2-butenedioic acid, (2E)-, dimethyl ester | Dimethylfumarate | BG 00012 | 00012, BG | BG00012 | BG-00012 | Tecfidera | FAG 201 | 201, FAG | FAG201 | FAG-201 | Fumaderm | BG 12 compound | 12 compound, BG | compound, BG 12 | BG12 compound | compound, BG12 | BG-12 compound
Chemical Information
Molecular Formula C6H8O4
CAS Registry Number 624-49-7
SMILES COC(=O)C=CC(=O)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cervix carcinoma21.06.02.001; 16.12.01.0010.011919%Not Available
Change of bowel habit07.02.03.0020.002751%Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.0010.054093%
Choking22.02.05.0010.010085%Not Available
Choking sensation22.02.05.002; 19.01.02.0020.004584%Not Available
Cholangiocarcinoma16.07.01.002; 09.04.02.0090.000478%Not Available
Cholecystitis09.03.01.0010.006418%
Cholelithiasis09.03.01.0020.026588%Not Available
Chorioretinitis11.01.06.010; 06.04.06.0030.001834%Not Available
Chromaturia20.02.01.0020.069679%
Chronic lymphocytic leukaemia01.10.06.001; 16.01.06.0010.001674%Not Available
Chronic myeloid leukaemia16.01.07.001; 01.10.07.0010.001196%Not Available
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Circulatory collapse24.06.02.001--Not Available
Clavicle fracture15.08.03.010; 12.04.01.0100.003667%Not Available
Clostridium difficile colitis07.19.01.004; 11.02.02.004--Not Available
Clumsiness17.01.02.0050.007335%Not Available
Coagulopathy01.01.02.001--Not Available
Cold sweat23.02.03.002; 08.01.03.0240.010085%Not Available
Colitis07.08.01.0010.021087%
Colitis ischaemic24.04.08.012; 07.08.01.0040.004584%Not Available
Colitis ulcerative07.08.01.005; 10.02.01.004--Not Available
Colon cancer16.13.01.001; 07.21.01.0010.002870%Not Available
Coma17.02.09.001--Not Available
Completed suicide08.04.01.010; 19.12.01.001--Not Available
Complex partial seizures17.12.02.0030.002751%Not Available
Concussion17.11.01.004; 12.01.10.0050.013753%Not Available
Confusional state19.13.01.001; 17.02.03.0050.113688%
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