Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Diazepam
Drug ID BADD_D00648
Description A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589) Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the formulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016 [L5200]. Combining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential for complete, consistent drug absorption and rapid onset of effect [L5200]. This current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy [L5200].
Indications and Usage Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Marketing Status Prescription; Discontinued
ATC Code N05BA01
DrugBank ID DB00829
KEGG ID D00293
MeSH ID D003975
PubChem ID 3016
TTD Drug ID D07JVL
NDC Product Code 0904-7117; 43063-970; 80425-0151; 70518-0162; 71872-7259; 52584-213; 68071-3330; 70518-1856; 70518-1270; 51862-943; 11014-0401; 68071-4899; 51862-942; 51862-941; 69339-136; 71610-427; 80425-0120; 71872-7260; 0140-0005; 69339-137; 67544-019; 0527-1767; 50090-3390; 0615-7800; 35356-812; 43353-278; 0378-0477; 61919-409; 11014-0400; 66490-650; 43353-281; 51079-286; 71554-118; 49452-2538; 63187-867; 68682-650; 67296-0291; 0409-1273; 71335-0444; 71610-460; 67296-0084; 12828-0013; 52584-273; 50090-4566; 45865-423; 63187-173; 58118-0640; 71610-424; 60760-934; 0527-1768; 0409-3213; 70518-2358; 0395-8143; 71610-270; 72252-510; 11014-0399; 55154-5074; 45865-482; 50090-1726; 68788-7452; 43353-825; 61919-906; 64330-010; 68071-4181; 51079-284; 0378-0345; 71610-459; 58118-4047; 61919-071; 68682-655; 68071-4770; 38779-0925; 63187-544; 68071-4829; 50090-0195; 0187-0659; 50090-2249; 45865-140; 11704-600; 71335-1584; 0378-0271; 48087-0005; 51927-0051; 72189-193; 0054-3188; 0641-6244; 63187-846; 53002-3340; 72252-520; 51552-1025; 0140-0006; 0140-0004; 58118-3926; 55289-092; 0172-3926; 70518-1713; 50090-1913; 0615-7799; 68682-652; 0121-0905; 63739-073; 80725-006; 63629-1523; 72252-515; 58118-3925; 43063-840; 55700-058; 51927-1014; 72252-505; 63629-2948; 60760-927; 43063-718; 48087-0112; 67544-020; 80725-004; 0172-3927; 55154-7885; 68071-3270; 0904-5880; 68071-4922; 80725-005; 0404-9848; 0187-0658; 50090-4713; 72572-140; 63629-7328; 49999-018; 68788-9207; 43063-987; 43353-276; 51079-285; 68094-750; 0172-3925; 70518-0014
Synonyms Diazepam | 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one | Diazemuls | Faustan | Valium | Seduxen | Sibazon | Stesolid | Apaurin | Relanium
Chemical Information
Molecular Formula C16H13ClN2O
CAS Registry Number 439-14-5
SMILES CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
AmnesiaTranslocator proteinP30536T754401352055; 10525757; 10428415; 10780255; 12845414; 8740046; 10884566; 7902274; 15501303; 10368858; 7913225; 2844992; 6147788; 11007074; 8234145
Anxiety disorderTranslocator proteinP30536T754401352055; 10525757; 10428415; 10780255; 12845414; 8740046; 10884566; 7902274; 15501303; 10368858; 7913225; 2844992; 6147788; 11007074; 8234145
SedationCytochrome P450 2C19P33261Not AvailableNot Available
SedationTranslocator proteinP30536T754401352055; 10525757; 10428415; 10780255; 12845414; 8740046; 10884566; 7902274; 15501303; 10368858; 7913225; 2844992; 6147788; 11007074; 8234145
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal faeces07.01.03.001--Not Available
Abortion spontaneous18.01.04.001--Not Available
Abscess11.01.08.0010.000213%Not Available
Acidosis14.01.03.0020.000427%
Acoustic stimulation tests abnormal13.07.01.0040.000056%Not Available
Activated partial thromboplastin time shortened13.01.02.0200.000320%Not Available
Acute hepatic failure09.01.03.0010.000854%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Acute respiratory distress syndrome22.01.03.0010.000223%
Acute respiratory failure22.02.06.001; 14.01.04.0040.000320%Not Available
Affective disorder19.04.04.0010.000213%Not Available
Aggression19.05.01.0010.001814%Not Available
Agitation19.06.02.001; 17.02.05.0120.007256%
Agranulocytosis01.02.03.0010.001067%Not Available
Akathisia19.06.02.006; 17.01.02.0020.000320%
Alanine aminotransferase increased13.03.01.003--
Alcohol abuse19.07.02.0070.001814%Not Available
Altered state of consciousness19.07.01.003; 17.02.04.0010.004268%Not Available
Amblyopia06.02.01.001--Not Available
Amnesia19.20.01.001; 17.03.02.0010.001601%
Anaemia01.03.02.001--
Anaesthetic complication pulmonary22.02.07.005; 12.02.12.0070.000320%Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anger19.04.02.001--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anorectal disorder07.03.01.001--Not Available
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