Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dextromethorphan
Drug ID BADD_D00638
Description Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse.[A215412] Although similar in structure to other opioids, it has minimal interaction with opioid receptors.[A215412] Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997]
Indications and Usage For treatment and relief of dry cough.
Marketing Status OTC
ATC Code R05DA09
DrugBank ID DB00514
KEGG ID D03742
MeSH ID D003915
PubChem ID 5360696
TTD Drug ID D09OBB
NDC Product Code 76206-004; 50090-0224; 58793-015; 71598-015; 70518-1912; 17856-0172; 58593-295; 70761-102; 76206-005; 75663-005; 75663-004; 62331-004; 60155-003
Synonyms Dextromethorphan | d-Methorphan | Dextromethorphan, (+-)-Isomer | l-Methorphan | Levomethorphan | Dextromethorphan Hydrobromide, Monohydrate | Delsym | Dextromethorphan Hydrobromide | Hydrobromide, Dextromethorphan | Dextromethorphan Hydrobromide, (+-)-Isomer | Dextromethorphan Hydrochloride | Hydrochloride, Dextromethorphan | Racemethorphan
Chemical Information
Molecular Formula C18H25NO
CAS Registry Number 125-71-3
SMILES CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Agitation19.06.02.001; 17.02.05.0120.004935%
Asthenia08.01.01.001--Not Available
Cardiac arrest02.03.04.0010.002575%
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Death08.04.01.001--
Diarrhoea07.02.01.0010.007403%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.004935%
Drug abuse19.07.02.0100.021887%Not Available
Dyspepsia07.01.02.001--
Erythema23.03.06.0010.004935%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.004935%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Hallucination19.10.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.0280.004935%
Hypersensitivity10.01.03.0030.004935%
Hypoglycaemia14.06.03.001; 05.06.03.001--
Immune system disorder10.02.01.001--Not Available
Irritability19.04.02.013; 08.01.03.011--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Respiratory arrest22.02.01.0090.002575%Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Serotonin syndrome17.05.02.004; 15.05.04.016; 12.03.01.041--Not Available
Somnolence19.02.05.003; 17.02.04.006--
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