Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dexamethasone
Drug ID BADD_D00623
Description Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions.[L10701] Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone].[A188724] Dexamethasone was granted FDA approval on 30 October 1958.[L10695] In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.[L14318]
Indications and Usage
Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps
Marketing Status Prescription; Discontinued
ATC Code A01AC02; C05AA09; D07AB19; D07XB05; D10AA03; H02AB02; R01AD03; S01BA01; S01CB01; S02BA06; S03BA01
DrugBank ID DB01234
KEGG ID D00292
MeSH ID D003907
PubChem ID 5743
TTD Drug ID D0IT2G
NDC Product Code 42195-127; 42195-721; 55718-156; 0121-0907; 70518-1534; 69306-112; 15014-211; 68071-2321; 79572-012; 63187-383; 55154-4914; 55289-903; 45865-989; 57582-031; 68788-7142; 63629-4127; 43063-266; 68788-7267; 51552-0430; 63629-7850; 55718-157; 61919-269; 71879-001; 47781-914; 0054-4180; 0023-3348; 55700-961; 0054-8175; 55700-854; 72189-254; 71205-013; 60219-2043; 67296-1413; 60219-2044; 67296-0326; 0054-8180; 0054-8179; 51407-361; 47781-916; 42195-121; 48102-051; 63629-3742; 22552-0039; 70382-204; 68071-4127; 38779-0405; 55154-4901; 70518-3050; 42195-221; 55289-582; 71161-138; 42195-270; 42195-151; 0054-4184; 63629-4129; 54879-003; 60432-466; 0054-3177; 52128-170; 50090-0089; 50090-0091; 72893-015; 0054-4183; 0054-8176; 48102-050; 0054-4186; 64980-509; 0395-8142; 71205-012; 61919-827; 50090-0088; 50090-0090; 82298-111; 65089-0045; 70518-2998; 0054-4179; 46439-8765; 49999-059; 0054-4181; 48102-049; 51927-1081; 69306-111; 49452-2465; 0054-8174; 63629-7806; 0998-0615; 0009-5019; 42195-149; 0054-4182; 48102-052; 0121-1814; 55718-133; 0054-8181; 42195-490; 0054-8183; 48102-047; 69306-114; 79043-200; 60722-3013; 63187-561
Synonyms Dexamethasone | Methylfluorprednisolone | Hexadecadrol | Decameth | Decaspray | Dexasone | Dexpak | Maxidex | Millicorten | Oradexon | Decaject | Decaject-L.A. | Decaject L.A. | Hexadrol
Chemical Information
Molecular Formula C22H29FO5
CAS Registry Number 50-02-2
SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisMitogen-activated protein kinase 11Q15759T557299266970; 9343388; 8978296; 9642282; 10026138; 10085120; 10419875
ApoptosisInterferon alpha-7P01567Not Available9743325; 11986233; 14632778; 12384432
ApoptosisTSC22 domain family protein 3Q99576Not Available9430225; 9177197; 9160677; 11468175; 15031210; 8598462; 7545465
ApoptosisRibosomal protein S6 kinase beta-1P23443T944799266970; 9343388; 8978296; 9642282; 10026138; 10085120; 10419875
ApoptosisPoly [ADP-ribose] polymerase 1Q9ZP54Not Available9266970; 9343388; 8978296; 9642282; 10026138; 10085120; 10419875
ApoptosisSignal transducer and activator of transcription 3P40763T291309743325; 11986233; 14632778; 12384432
ApoptosisDual specificity mitogen-activated protein kinase kinase 7Q8CE90Not Available9266970; 9343388; 8978296; 9642282; 10026138; 10085120; 10419875
ApoptosisInterleukin-6P05231T325789743325; 11986233; 14632778; 12384432
ApoptosisC-Jun-amino-terminal kinase-interacting protein 1Q9UQF2T594599266970; 9343388; 8978296; 9642282; 10026138; 10085120; 10419875
ApoptosisSignal transducer and activator of transcription 3P40763T2913010564544; 14647067
Bone disorderAlkaline phosphatase, placental typeP05187Not Available10760957; 9556063; 10699973; 15647827
Bone disorderCadherin-11P55287T2838510760957; 9556063; 10699973; 15647827
Bone disorderCadherin-4P55283Not Available10760957; 9556063; 10699973; 15647827
Bone disorderCadherin-12P55289Not Available10760957; 9556063; 10699973; 15647827
Cushing's syndromeSolute carrier family 2, facilitated glucose transporter member 4P14672T676587627333; 11720905; 9483380
Deep vein thrombosisThrombomodulinP07204T0858315235749; 7878634
Gastrointestinal disordersAromatic-L-amino-acid decarboxylaseP20711T621932036598; 8638714; 2734586; 56028; 3138918; 8898415; 2409817; 14045; 9068065; 9361993; 8074225; 2492156; 3345508; 11301043; 9298521; 10395406; 14759558; 9756494; 6824087; 1220545
Gastrointestinal disordersOrnithine decarboxylaseP11926T603662036598; 8638714; 2734586; 56028; 3138918; 8898415; 2409817; 14045; 9068065; 9361993; 8074225; 2492156; 3345508; 11301043; 9298521; 10395406; 14759558; 9756494; 6824087; 1220545
Gastrointestinal disordersHistidine decarboxylaseQ8L0Z4Not Available2036598; 8638714; 2734586; 56028; 3138918; 8898415; 2409817; 14045; 9068065; 9361993; 8074225; 2492156; 3345508; 11301043; 9298521; 10395406; 14759558; 9756494; 6824087; 1220545
Gastrointestinal disordersGastrinP01350T161282036598; 8638714; 2734586; 56028; 3138918; 8898415; 2409817; 14045; 9068065; 9361993; 8074225; 2492156; 3345508; 11301043; 9298521; 10395406; 14759558; 9756494; 6824087; 1220545
Hearing lossesMyelin protein P0P27573Not Available25830874
Hearing lossesHeat shock 70 kDa protein 1BP17879Not Available25830874
Hepatic steatosisHaptoglobinP00738T177108317760; 7978646; 8286556; 11853146; 7701779; 1626786; 8357927
Hepatic steatosisProtein kinase C delta typeQ05655T448618317760; 7978646; 8286556; 11853146; 7701779; 1626786; 8357927
HyperglycaemiaSulfotransferase 1A1P52840Not Available8039608; 8182132; 2912706
InjurySignal transducer and activator of transcription 3P40763T2913010564544; 14647067
InjuryHeme oxygenase 1P09601T2570310564544; 9530200; 10874044
InjurySignal transducer and activator of transcription 3P40763T291309743325; 11986233; 14632778; 12384432
InvestigationsIslet amyloid polypeptideP10997T562691282477; 2190214; 2384600; 7796979
InvestigationsInsulinP01308T828411282477; 2190214; 2384600; 7796979
Liver injuryAlanine aminotransferase 1Q8QZR5Not Available25900201
Myeloid leukaemiaInterleukin-4P05112T002398275499; 1906157; 1936261; 1588953; 7951003; 7811994; 1901940; 10497240
Plasma cell myelomaC-Jun-amino-terminal kinase-interacting protein 1Q9UQF2T594599266970; 9343388; 8978296; 9642282; 10026138; 10085120; 10419875
Plasma cell myelomaDual specificity mitogen-activated protein kinase kinase 7Q8CE90Not Available9266970; 9343388; 8978296; 9642282; 10026138; 10085120; 10419875
PneumoniaNuclear factor NF-kappa-B p105 subunitP19838T401929875241; 12028809; 8079820
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood corticotrophin increased13.10.03.0140.001373%Not Available
Borderline glaucoma06.03.01.0050.000687%Not Available
Brain neoplasm malignant16.30.04.002; 17.20.04.0020.000179%Not Available
Brief psychotic disorder, with postpartum onset19.03.05.002; 18.06.03.0010.000687%Not Available
Catabolic state14.11.01.0340.001373%Not Available
Cellulitis orbital06.04.11.001; 11.02.01.0350.000179%Not Available
Dermatitis exfoliative generalised10.01.01.029; 23.03.07.0020.000687%Not Available
Disseminated cryptococcosis11.03.04.0040.000179%Not Available
Ductus arteriosus stenosis foetal24.03.03.027; 03.07.09.0060.001030%Not Available
Electrocardiogram Q waves13.14.05.0390.000537%Not Available
Eye infection toxoplasmal11.06.01.003; 06.04.05.0270.001030%Not Available
Familial periodic paralysis17.19.02.007; 03.10.01.0080.001030%Not Available
Full blood count decreased13.01.07.0040.003090%Not Available
Heart block congenital03.07.07.003; 02.03.01.0210.000985%Not Available
Intraventricular haemorrhage neonatal24.07.04.029; 18.04.16.002; 17.08.01.0530.000179%Not Available
Laboratory test interference13.18.01.0080.000687%Not Available
Lymphadenopathy mediastinal01.09.01.025; 22.09.03.0060.000687%Not Available
Malignant melanoma in situ23.08.01.004; 16.03.01.0040.000687%Not Available
Maternal drugs affecting foetus18.03.03.009; 12.03.03.0060.003776%Not Available
Metastases to bone16.22.02.005; 15.09.03.0060.000687%Not Available
Neonatal respiratory distress syndrome22.11.02.010; 18.04.10.0030.002403%Not Available
Nosocomial infection11.07.02.0060.000179%Not Available
Open angle glaucoma06.03.01.0040.001030%Not Available
Placental insufficiency24.04.12.002; 18.05.02.0060.001030%Not Available
Purulent discharge11.01.08.061; 08.01.03.0760.000687%Not Available
Renin increased13.09.02.0040.000687%Not Available
Small for dates baby18.04.02.0020.000687%Not Available
Vitritis06.04.06.0130.002060%Not Available
Cerebral ventricle dilatation17.11.01.0130.000687%Not Available
Live birth18.08.02.0070.003090%Not Available
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