Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Apoptosis
ADR Hierarchy
14      Metabolism and nutrition disorders
14.11      Metabolism disorders NEC
14.11.02      Cell metabolism disorders NEC      Apoptosis
Description One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. | Apoptosis that is triggered via cell stress and mitochondrial damage. | Apoptosis that is triggered via CELL SURFACE RECEPTORS such as TUMOR NECROSIS FACTOR RECEPTORS and DEATH DOMAIN RECEPTORS. [MeSH]
MedDRA Code 10059512
MeSH ID D017209
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Intestinal villi apoptosis | Duodenal villi apoptosis | Apoptotic DNA damage | Apoptosis | Programmed Cell Death, Type I | Apoptosis, Intrinsic Pathway | Apoptoses, Intrinsic Pathway | Intrinsic Pathway Apoptoses | Intrinsic Pathway Apoptosis | Apoptosis, Extrinsic Pathway | Apoptoses, Extrinsic Pathway | Extrinsic Pathway Apoptoses | Extrinsic Pathway Apoptosis
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Acute lymphocytic leukemia (ALL) BCR-ABL mRNA encoding P185-ALL-ABL proteinQ13745Not Available
Alkaline phosphatase, tissue-nonspecific isozymeP05186T09538
Apoptosis regulator BAXQ07812T89251
Baculoviral IAP repeat-containing protein 2Q13490T84780
Baculoviral IAP repeat-containing protein 3Q13489T35173
Bcl2-associated agonist of cell deathQ92934Not Available
C-Jun-amino-terminal kinase-interacting protein 1Q9UQF2T59459
Cellular tumor antigen p53P04637T15739
Cellular tumor antigen p53P10361Not Available
Cyclic AMP-dependent transcription factor ATF-2P16951Not Available
Cyclin-dependent kinase 20Q8IZL9Not Available
DNA topoisomerase 1P11387T09826
DNA topoisomerase 2-alphaP11388T17048
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1P61803Not Available
Dual specificity mitogen-activated protein kinase kinase 7Q8CE90Not Available
Dystroglycan 1Q14118T63883
E3 ubiquitin-protein ligase Mdm2P23804Not Available
Early growth response protein 1P18146T32348
Epidermal growth factor receptorP00533T59328
Focal adhesion kinase 1Q05397T15068
G1/S-specific cyclin-D1P24385T12355
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1Q06210Not Available
Glutathione S-transferase PP04906Not Available
Golgi SNAP receptor complex member 1O95249Not Available
Heat shock protein HSP 90-alphaP07900T18477
Interferon alpha-7P01567Not Available
Latent-transforming growth factor beta-binding protein 1Q14766Not Available
Lipoprotein lipaseP06858T28692
Mitogen-activated protein kinase 1P28482T58970
Mitogen-activated protein kinase 11Q15759T55729
Mitogen-activated protein kinase 14Q16539T65864
Mitogen-activated protein kinase 8P45983T40097
NAD-dependent protein deacetylase sirtuin-1Q96EB6T14731
NADP-dependent oxidoreductase 3W4JPE0Not Available
Nitric oxide synthase, brainP29475T16117
Noc7E5DUJ3Not Available
Nuclear factor NF-kappa-B p105 subunitP19838T40192
Nuclear receptor subfamily 4 group A member 3Q92570T93949
p21 proteinP78460Not Available
Peroxisome proliferator-activated receptor gammaP37231T58921
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformP42337Not Available
Poly [ADP-ribose] polymerase 1Q9ZP54Not Available
Pre-mRNA-processing factor 19Q9UMS4Not Available
Protein c-FosP01100T28025
Protein kinase C beta typeP05771T40276
Protein kinase C delta typeQ05655T44861
Proto-oncogene serine/threonine-protein kinase mosP00540Not Available
Putative cyclin-dependent kinase inhibitor 1A (P21/WAF1/CIP1)Q683K8Not Available
RAC-alpha serine/threonine-protein kinaseP31749T67619
RAC-alpha serine/threonine-protein kinaseP31750Not Available
Renin receptorQ9CYN9Not Available
Ribosomal protein S6 kinase beta-1P23443T94479
S-adenosylhomocysteine hydrolase-like protein 1O43865Not Available
Serine/threonine-protein kinase mTORQ9JLN9Not Available
Signal transducer and activator of transcription 3P40763T29130
Soluble TNF receptor IIP68636Not Available
Superoxide dismutaseQ4ZJI1Not Available
Thymidine kinase, cytosolicP04183T30081
TNF receptor-associated factor 1Q13077Not Available
Transcription factor JunP05412T69085
Transcription factor JunP05627Not Available
TSC22 domain family protein 3Q99576Not Available
Tyrosine-protein phosphatase non-receptor type 12Q05209Not Available
von Willebrand factorP04275T23348
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01507Mycophenolate mofetil0.003582%
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