Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Demeclocycline hydrochloride
Drug ID BADD_D00606
Description A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Indications and Usage Used primarily to treat Lyme disease, acne, and bronchitis. Also indicated (but rarely used) to treat urinary tract infections, gum disease, malaria, and other bacterial infections such as gonorrhea and chlamydia. One of its other registered uses is the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective.
Marketing Status Prescription; Discontinued
ATC Code D06AA01; J01AA01
DrugBank ID DB00618
KEGG ID D00290
MeSH ID D003707
PubChem ID 54686764
TTD Drug ID D0R9WP
NDC Product Code 42806-143; 24658-711; 60429-649; 42806-144; 52972-0030; 61748-113; 62584-159; 62584-163; 61748-115; 24658-710; 60429-663
Synonyms Demeclocycline | Demethylchlortetracycline | Declomycin | Lédermycine | Ledermycin | Demeclocycline, Calcium (1:1) Salt | Demeclocycline Monohydrochloride | Monohydrochloride, Demeclocycline | Demeclocycline, 4-epimer | Demeclocycline, Calcium (1:2) Salt | Demeclocycline Hydrochloride | Hydrochloride, Demeclocycline
Chemical Information
Molecular Formula C21H22Cl2N2O8
CAS Registry Number 64-73-3
SMILES CN(C)C1C2CC3C(C4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arthralgia15.01.02.001--
Balanoposthitis21.09.03.001--Not Available
Benign intracranial hypertension17.07.02.001--Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood urea increased13.13.01.006--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Dysphagia07.01.06.003--
Enterocolitis07.08.03.003--
Eosinophilia01.02.04.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fixed drug eruption10.01.01.022; 08.01.06.017; 23.03.05.006--Not Available
Fontanelle bulging18.04.04.001; 17.02.05.006--Not Available
Glossitis07.14.01.001--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Henoch-Schonlein purpura24.07.06.003; 23.06.01.002; 01.01.04.001; 10.02.02.004--Not Available
Hepatic failure09.01.03.002--
Hepatitis09.01.07.004--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Lung infiltration22.01.02.004--Not Available
Myasthenic syndrome16.32.01.002; 15.05.08.003; 10.04.05.005; 17.05.04.004--Not Available
Nausea07.01.07.001--
Nephrogenic diabetes insipidus20.05.03.010; 14.05.07.002--Not Available
Neutropenia01.02.03.004--Not Available
Pancreatitis07.18.01.001--
Pericarditis02.06.02.001--
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