Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Deferasirox
Drug ID BADD_D00594
Description Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Indications and Usage For the treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age and older.
Marketing Status Prescription
ATC Code V03AC03
DrugBank ID DB01609
KEGG ID D03669
MeSH ID D000077588
PubChem ID 214348
TTD Drug ID D0Q5UQ
NDC Product Code 62332-412; 43598-856; 57664-769; 62332-411; 62756-569; 0078-0469; 70771-1411; 66039-871; 69097-550; 70771-1471; 72647-371; 62512-0078; 68462-494; 69539-021; 31722-012; 69097-391; 57664-770; 58032-2017; 69539-200; 63278-1070; 72647-372; 46708-324; 69452-159; 62332-410; 53104-7713; 72606-014; 11722-040; 69097-570; 43598-851; 62332-324; 67877-549; 69539-022; 66022-0301; 0591-3853; 45963-456; 14501-0049; 46708-410; 62332-325; 46708-879; 72606-013; 62756-570; 69238-1486; 43598-854; 65085-0063; 62332-326; 69238-1704; 70710-1011; 59285-010; 46708-326; 70710-1012; 59651-419; 16714-995; 69539-199; 72205-076; 65727-037; 74436-0323; 57664-768; 68462-495; 46708-325; 69452-160; 0078-0713; 65015-738; 16714-993; 69097-393; 69097-560; 0078-0470; 31722-013; 69539-074; 43598-853; 70700-269; 70771-1409; 49706-2103; 70710-1277; 43598-855; 0078-0468; 65372-1164; 16714-994; 43598-852; 45963-455; 46708-412; 0078-0727; 70771-1472; 72647-373; 68462-496; 67877-553; 69238-1703; 45963-454; 69452-161; 0078-0654; 62756-568; 70771-1473; 69539-023; 67877-550; 0078-0720; 70710-1275; 31722-011; 72606-015; 70771-1410; 69539-075; 67877-551; 70710-1013; 67877-554; 72205-075; 0078-0656; 70700-270; 69238-1702; 0078-0655; 46708-411; 69097-392; 69539-073; 69238-1487; 67877-552; 70700-271; 70710-1276; 69238-1488
Synonyms Deferasirox | 4-(3,5-Bis-(2-hydroxyphenyl)-(1,2,4)-triazol-1-yl)benzoic acid | ICL 670A | ICL-670A | ICL670A | ICL-670 | ICL670 | ICL 670 | Exjade
Chemical Information
Molecular Formula C21H15N3O4
CAS Registry Number 201530-41-8
SMILES C1=CC=C(C(=C1)C2=NN(C(=N2)C3=CC=CC=C3O)C4=CC=C(C=C4)C(=O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Back pain15.03.04.0050.104961%
Bacteraemia11.01.11.0010.003042%
Basal cell carcinoma23.08.02.001; 16.03.02.001--Not Available
Bile duct stone09.02.02.0030.005831%Not Available
Bilirubin conjugated increased13.03.01.0070.005831%Not Available
Bladder cancer20.03.04.001; 16.08.01.001--Not Available
Blindness17.17.01.003; 06.02.02.0010.026240%Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood albumin decreased13.09.01.0010.005831%Not Available
Blood albumin increased13.09.01.0020.005831%Not Available
Blood bicarbonate decreased13.11.01.0190.005831%
Blood bilirubin increased13.03.01.0080.055396%
Blood calcium decreased13.11.01.0020.011662%Not Available
Blood calcium increased13.11.01.0030.005831%Not Available
Blood creatine increased13.13.01.0010.023325%Not Available
Blood creatinine abnormal13.13.01.0020.017494%Not Available
Blood creatinine increased13.13.01.0040.384858%
Blood culture positive13.08.02.0020.005831%Not Available
Blood glucose abnormal13.02.02.0080.005831%Not Available
Blood glucose decreased13.02.02.0010.017494%Not Available
Blood glucose increased13.02.02.002--Not Available
Blood iron decreased13.11.01.0060.023325%Not Available
Blood iron increased13.11.01.0070.134117%Not Available
Blood lactate dehydrogenase increased13.04.02.0020.017494%
Blood magnesium decreased13.11.01.0080.005831%Not Available
Blood pH decreased13.02.01.0160.001521%Not Available
Blood potassium decreased13.11.01.0100.043734%Not Available
Blood potassium increased13.11.01.0110.026240%Not Available
Blood pressure abnormal13.14.03.001--Not Available
Blood pressure decreased13.14.03.0020.040818%Not Available
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