Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Delayed puberty
ADR ID BADD_A01176
ADR Hierarchy
05      Endocrine disorders
05.05      Endocrine disorders of gonadal function
05.05.03      Endocrine abnormalities of puberty
05.05.03.003      Delayed puberty
21      Reproductive system and breast disorders
21.03      Sexual function and fertility disorders
21.03.02      Sexual function and fertility disorders NEC
21.03.02.014      Delayed puberty
Description A disorder characterized by unusually late sexual maturity. [CTCAE] The lack of development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations above the mean age at onset of PUBERTY in a population. Delayed puberty can be classified by defects in the hypothalamic LHRH pulse generator, the PITUITARY GLAND, or the GONADS. These patients will undergo spontaneous but delayed puberty whereas patients with SEXUAL INFANTILISM will not. [MeSH]
MedDRA Code 10012205
MeSH ID D011628
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Delay in sexual development and puberty, not elsewhere classified | Delayed puberty | Female sex maturation retarded | Male sex maturation retarded | Delayed male sexual development | Delayed female sexual development | Puberty, Delayed | Delayed Puberty
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Growth hormone receptorP16882Not Available
Receptor protein-tyrosine kinaseQ6QHH2Not Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00306Budesonide0.000609%
BADD_D00318Busulfan--
BADD_D00594Deferasirox0.008747%
BADD_D00648Diazepam0.000213%
BADD_D01073Histrelin0.005148%
BADD_D01285Levothyroxine0.000034%
BADD_D01431Methylphenidate0.000367%
BADD_D01834Prednisone0.000040%
BADD_D02355Vigabatrin--
BADD_D02492Deflazacort0.000331%
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