Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Deferasirox
Drug ID BADD_D00594
Description Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Indications and Usage For the treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age and older.
Marketing Status Prescription
ATC Code V03AC03
DrugBank ID DB01609
KEGG ID D03669
MeSH ID D000077588
PubChem ID 214348
TTD Drug ID D0Q5UQ
NDC Product Code 62332-412; 43598-856; 57664-769; 62332-411; 62756-569; 0078-0469; 70771-1411; 66039-871; 69097-550; 70771-1471; 72647-371; 62512-0078; 68462-494; 69539-021; 31722-012; 69097-391; 57664-770; 58032-2017; 69539-200; 63278-1070; 72647-372; 46708-324; 69452-159; 62332-410; 53104-7713; 72606-014; 11722-040; 69097-570; 43598-851; 62332-324; 67877-549; 69539-022; 66022-0301; 0591-3853; 45963-456; 14501-0049; 46708-410; 62332-325; 46708-879; 72606-013; 62756-570; 69238-1486; 43598-854; 65085-0063; 62332-326; 69238-1704; 70710-1011; 59285-010; 46708-326; 70710-1012; 59651-419; 16714-995; 69539-199; 72205-076; 65727-037; 74436-0323; 57664-768; 68462-495; 46708-325; 69452-160; 0078-0713; 65015-738; 16714-993; 69097-393; 69097-560; 0078-0470; 31722-013; 69539-074; 43598-853; 70700-269; 70771-1409; 49706-2103; 70710-1277; 43598-855; 0078-0468; 65372-1164; 16714-994; 43598-852; 45963-455; 46708-412; 0078-0727; 70771-1472; 72647-373; 68462-496; 67877-553; 69238-1703; 45963-454; 69452-161; 0078-0654; 62756-568; 70771-1473; 69539-023; 67877-550; 0078-0720; 70710-1275; 31722-011; 72606-015; 70771-1410; 69539-075; 67877-551; 70710-1013; 67877-554; 72205-075; 0078-0656; 70700-270; 69238-1702; 0078-0655; 46708-411; 69097-392; 69539-073; 69238-1487; 67877-552; 70700-271; 70710-1276; 69238-1488
Synonyms Deferasirox | 4-(3,5-Bis-(2-hydroxyphenyl)-(1,2,4)-triazol-1-yl)benzoic acid | ICL 670A | ICL-670A | ICL670A | ICL-670 | ICL670 | ICL 670 | Exjade
Chemical Information
Molecular Formula C21H15N3O4
CAS Registry Number 201530-41-8
SMILES C1=CC=C(C(=C1)C2=NN(C(=N2)C3=CC=CC=C3O)C4=CC=C(C=C4)C(=O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Serum ferritin abnormal13.11.01.0280.023325%Not Available
Thalassaemia beta01.04.03.002; 03.15.03.0030.005831%Not Available
Urinary bladder haemorrhage24.07.01.086; 20.03.01.0230.005831%Not Available
Kidney enlargement20.01.06.0030.008747%Not Available
Concomitant disease progression08.01.03.0640.003803%Not Available
Terminal state08.01.03.0790.008747%Not Available
Neck mass15.03.02.0070.005831%Not Available
Creatinine urine increased13.13.01.0280.005831%Not Available
Hepatic siderosis14.13.03.005; 09.01.10.0080.014578%Not Available
Acute chest syndrome22.06.03.004; 01.04.02.004; 24.03.08.0060.034987%Not Available
Leukaemic infiltration pulmonary22.08.01.016; 16.01.03.007; 01.10.03.0070.001521%Not Available
Cardiac infection02.01.05.002; 11.01.16.0030.001521%Not Available
Clostridium difficile infection11.02.02.009--Not Available
Growth hormone deficiency05.03.02.0040.005831%Not Available
Hepatic infection11.01.18.008; 09.01.08.0140.008747%
Gastric infection11.01.07.008; 07.19.03.0030.005831%Not Available
Hepatic mass09.01.08.0150.005831%Not Available
Cell death08.03.03.003; 14.11.02.0050.005831%Not Available
Parvovirus infection11.05.15.0010.005831%Not Available
Nephrogenic anaemia20.01.01.007; 01.03.04.0010.005831%Not Available
Carnitine deficiency14.08.04.0220.005831%Not Available
General physical condition abnormal13.15.01.0400.008747%Not Available
Blast cell count increased13.01.03.0080.005324%Not Available
Grip strength decreased13.15.01.0410.005831%Not Available
Cardiac siderosis14.13.03.003; 02.04.01.0070.003803%Not Available
Acute lymphocytic leukaemia recurrent16.01.01.003; 01.10.01.0030.001521%Not Available
Graft versus host disease in liver12.02.09.029; 10.02.01.060; 09.01.07.0330.001521%Not Available
Apparent death08.01.03.0620.008747%Not Available
Oncologic complication16.32.03.0250.001521%Not Available
Pure white cell aplasia01.03.03.0130.005831%Not Available
The 27th Page    First    Pre   27 28    Next   Last    Total 28 Pages