Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Deferasirox
Drug ID BADD_D00594
Description Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Indications and Usage For the treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age and older.
Marketing Status Prescription
ATC Code V03AC03
DrugBank ID DB01609
KEGG ID D03669
MeSH ID D000077588
PubChem ID 214348
TTD Drug ID D0Q5UQ
NDC Product Code 62332-412; 43598-856; 57664-769; 62332-411; 62756-569; 0078-0469; 70771-1411; 66039-871; 69097-550; 70771-1471; 72647-371; 62512-0078; 68462-494; 69539-021; 31722-012; 69097-391; 57664-770; 58032-2017; 69539-200; 63278-1070; 72647-372; 46708-324; 69452-159; 62332-410; 53104-7713; 72606-014; 11722-040; 69097-570; 43598-851; 62332-324; 67877-549; 69539-022; 66022-0301; 0591-3853; 45963-456; 14501-0049; 46708-410; 62332-325; 46708-879; 72606-013; 62756-570; 69238-1486; 43598-854; 65085-0063; 62332-326; 69238-1704; 70710-1011; 59285-010; 46708-326; 70710-1012; 59651-419; 16714-995; 69539-199; 72205-076; 65727-037; 74436-0323; 57664-768; 68462-495; 46708-325; 69452-160; 0078-0713; 65015-738; 16714-993; 69097-393; 69097-560; 0078-0470; 31722-013; 69539-074; 43598-853; 70700-269; 70771-1409; 49706-2103; 70710-1277; 43598-855; 0078-0468; 65372-1164; 16714-994; 43598-852; 45963-455; 46708-412; 0078-0727; 70771-1472; 72647-373; 68462-496; 67877-553; 69238-1703; 45963-454; 69452-161; 0078-0654; 62756-568; 70771-1473; 69539-023; 67877-550; 0078-0720; 70710-1275; 31722-011; 72606-015; 70771-1410; 69539-075; 67877-551; 70710-1013; 67877-554; 72205-075; 0078-0656; 70700-270; 69238-1702; 0078-0655; 46708-411; 69097-392; 69539-073; 69238-1487; 67877-552; 70700-271; 70710-1276; 69238-1488
Synonyms Deferasirox | 4-(3,5-Bis-(2-hydroxyphenyl)-(1,2,4)-triazol-1-yl)benzoic acid | ICL 670A | ICL-670A | ICL670A | ICL-670 | ICL670 | ICL 670 | Exjade
Chemical Information
Molecular Formula C21H15N3O4
CAS Registry Number 201530-41-8
SMILES C1=CC=C(C(=C1)C2=NN(C(=N2)C3=CC=CC=C3O)C4=CC=C(C=C4)C(=O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haematochezia24.07.02.012; 07.12.02.0030.064143%Not Available
Haematocrit decreased13.01.05.0010.043734%Not Available
Haematocrit increased13.01.05.0020.008747%Not Available
Haematoma24.07.01.001--
Haematuria24.07.01.047; 20.02.01.006--
Blood urine present13.13.02.0020.014578%Not Available
Haemochromatosis12.02.08.002; 09.01.10.005; 14.13.03.0010.012930%Not Available
Haemoglobin13.01.05.018--Not Available
Haemoglobin abnormal13.01.05.0110.011662%Not Available
Haemoglobin decreased13.01.05.0030.297390%Not Available
Haemoglobin increased13.01.05.0040.008747%
Haemoglobinuria20.02.01.017; 01.06.04.0050.005831%
Haemolysis01.06.04.0020.020409%
Haemolytic anaemia01.06.03.0020.014578%Not Available
Haemolytic uraemic syndrome20.01.03.011; 01.06.02.0010.005831%
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.0060.020409%Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.008--
Haemorrhage subcutaneous24.07.06.010; 23.06.07.0020.008747%Not Available
Haemorrhagic stroke24.07.04.014; 17.08.01.011--Not Available
Haemorrhoids24.10.02.002; 07.15.03.0010.008747%
Haemothorax24.07.01.008; 12.01.03.002; 22.05.02.0010.005831%
Hallucination19.10.02.002--
Headache17.14.01.001--
Heart rate increased13.14.04.002--Not Available
Hemiplegia17.01.04.0020.014578%Not Available
Henoch-Schonlein purpura23.06.01.002; 10.02.02.004; 24.07.06.003; 01.01.04.001--Not Available
Hepatic cirrhosis09.01.04.0010.009127%Not Available
Hepatic cyst16.06.02.001; 09.01.08.0080.005831%Not Available
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.017494%Not Available
Hepatic failure09.01.03.0020.016733%
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