Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Daunorubicin
Drug ID BADD_D00590
Description A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Indications and Usage For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults. Daunorubicin is indicated in combination with [cytarabine] for the treatment of newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC) in adults and pediatric patients 1 year and older.[L32843]
Marketing Status approved
ATC Code L01DB02
DrugBank ID DB00694
KEGG ID D07776
MeSH ID D003630
PubChem ID 30323
TTD Drug ID D01XWG
NDC Product Code Not Available
UNII ZS7284E0ZP
Synonyms Daunorubicin | Daunomycin | Rubomycin | Dauno-Rubidomycine | Dauno Rubidomycine | Rubidomycin | Daunoblastin | Daunoblastine | NSC-82151 | NSC 82151 | NSC82151 | Cerubidine | Daunorubicin Hydrochloride | Hydrochloride, Daunorubicin
Chemical Information
Molecular Formula C27H29NO10
CAS Registry Number 20830-81-3
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Menopausal symptoms21.02.02.002--Not Available
Mental disability26.01.01.001--Not Available
Mood swings19.04.03.001--Not Available
Mucosal inflammation08.01.06.002--Not Available
Myalgia15.05.02.001--
Myelodysplastic syndrome16.01.04.001; 01.10.04.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocarditis02.04.03.001--
Nail disorder23.02.05.002--
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Nocturia20.02.03.001--Not Available
Oedema08.01.07.006; 14.05.06.010--Not Available
Oesophagitis07.08.05.001--
Opportunistic infection11.01.08.007--Not Available
Pain08.01.08.004--
Palpitations02.11.04.012--
Pancytopenia01.03.03.003--Not Available
Pericardial effusion02.06.01.002--
Pericarditis02.06.02.001--
Polyuria20.02.03.002--Not Available
Proctalgia07.03.02.001--
Pruritus23.03.12.001--
Pulmonary hypertension24.08.03.002; 22.06.01.001--
Rash23.03.13.001--Not Available
Rash macular23.03.13.003--Not Available
Renal failure20.01.03.005--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
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ADReCS-Target
Drug Name ADR Term Target
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