Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dasatinib
Drug ID BADD_D00589
Description Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
Indications and Usage For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
Marketing Status Prescription
ATC Code L01EA02
DrugBank ID DB01254
KEGG ID D03658
MeSH ID D000069439
PubChem ID 3062316
TTD Drug ID D0E6XR
NDC Product Code 63285-862; 63285-867; 0003-0855; 63285-863; 63285-866; 63285-865; 68554-0070; 54893-0015; 54893-0047; 0003-0857; 0003-0852; 0003-0527; 0003-0528; 76302-014; 50193-0524; 46708-891; 14778-1313; 62207-973; 63285-864; 0003-0524; 59651-468; 53104-7725
Synonyms Dasatinib | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | Sprycel | (18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | BMS 354825 | 354825, BMS | BMS354825 | BMS-354825
Chemical Information
Molecular Formula C22H26ClN7O2S
CAS Registry Number 302962-49-8
SMILES CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eosinophil count increased13.01.06.0040.001066%Not Available
Eosinophilia01.02.04.001--
Eosinophilic pneumonia22.01.01.004; 01.02.04.0030.000533%Not Available
Epistaxis22.04.03.001; 24.07.01.005--
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Erythema nodosum23.07.02.001; 10.02.01.0200.000533%Not Available
Essential hypertension24.08.02.0080.000533%Not Available
Eye disorder06.08.03.0010.001598%Not Available
Eye haemorrhage06.07.02.001; 24.07.05.0020.002398%Not Available
Eye irritation06.04.05.003--Not Available
Eye pain06.08.03.002--
Eye swelling06.08.03.0030.005062%Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.0040.001598%Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.0030.002664%
Facial pain08.01.08.0120.000533%
Facial paralysis17.04.03.008--Not Available
Faeces discoloured07.01.03.0020.001865%Not Available
Faeces hard07.01.03.0030.000533%Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.000139%Not Available
Fatigue08.01.01.0020.104167%
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.0080.002398%Not Available
Feeling hot08.01.09.009--Not Available
Fibrosis08.03.01.0010.000799%Not Available
Flatulence07.01.04.0020.003463%
Fluid overload14.05.06.001; 02.05.04.0040.001066%Not Available
Fluid retention20.01.02.003; 14.05.06.0020.028506%Not Available
Flushing24.03.01.002; 08.01.03.025; 23.06.05.003--
The 8th Page    First    Pre   8 9 10 11 12    Next   Last    Total 30 Pages