Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dasatinib
Drug ID BADD_D00589
Description Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
Indications and Usage For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
Marketing Status Prescription
ATC Code L01EA02
DrugBank ID DB01254
KEGG ID D03658
MeSH ID D000069439
PubChem ID 3062316
TTD Drug ID D0E6XR
NDC Product Code 63285-862; 63285-867; 0003-0855; 63285-863; 63285-866; 63285-865; 68554-0070; 54893-0015; 54893-0047; 0003-0857; 0003-0852; 0003-0527; 0003-0528; 76302-014; 50193-0524; 46708-891; 14778-1313; 62207-973; 63285-864; 0003-0524; 59651-468; 53104-7725
Synonyms Dasatinib | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | Sprycel | (18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | BMS 354825 | 354825, BMS | BMS354825 | BMS-354825
Chemical Information
Molecular Formula C22H26ClN7O2S
CAS Registry Number 302962-49-8
SMILES CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Memory impairment19.20.01.003; 17.03.02.0030.007726%
Meningitis17.06.03.001; 11.01.03.0010.000208%
Menorrhagia21.01.03.002--
Menstrual disorder21.01.01.004--Not Available
Menstruation irregular05.05.01.008; 21.01.01.005--
Mental impairment19.21.02.003; 17.03.03.002--Not Available
Mesothelioma16.39.01.0010.000533%Not Available
Middle insomnia19.02.01.003; 17.15.03.003--Not Available
Migraine24.03.05.003; 17.14.02.0010.008259%Not Available
Milia23.02.03.011--Not Available
Miliaria23.02.03.014--Not Available
Mitral valve incompetence02.07.01.0020.000799%Not Available
Mood altered19.04.02.007--Not Available
Mood swings19.04.03.001--Not Available
Mouth haemorrhage24.07.02.014; 07.05.02.0010.000533%
Mouth ulceration07.05.06.004--Not Available
Mucosal inflammation08.01.06.002--Not Available
Muscle spasms15.05.03.0040.013054%
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.0070.009058%
Myalgia15.05.02.0010.021046%
Myelodysplastic syndrome16.01.04.001; 01.10.04.001--
Myocardial infarction02.02.02.007; 24.04.04.009--
Myocarditis02.04.03.001--
Myopathy15.05.05.001--Not Available
Myositis15.05.01.001--
Nail discolouration23.02.05.0010.000799%
Nail disorder23.02.05.0020.000533%
Nasal congestion22.04.04.001--
Nasopharyngitis22.07.03.002; 11.01.13.0020.010124%Not Available
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