Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dasatinib
Drug ID BADD_D00589
Description Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
Indications and Usage For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
Marketing Status Prescription
ATC Code L01EA02
DrugBank ID DB01254
KEGG ID D03658
MeSH ID D000069439
PubChem ID 3062316
TTD Drug ID D0E6XR
NDC Product Code 63285-862; 63285-867; 0003-0855; 63285-863; 63285-866; 63285-865; 68554-0070; 54893-0015; 54893-0047; 0003-0857; 0003-0852; 0003-0527; 0003-0528; 76302-014; 50193-0524; 46708-891; 14778-1313; 62207-973; 63285-864; 0003-0524; 59651-468; 53104-7725
Synonyms Dasatinib | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | Sprycel | (18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | BMS 354825 | 354825, BMS | BMS354825 | BMS-354825
Chemical Information
Molecular Formula C22H26ClN7O2S
CAS Registry Number 302962-49-8
SMILES CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Large intestinal ulcer07.04.06.0040.000533%
Laryngeal cancer22.08.02.001; 16.19.03.0010.000533%Not Available
Left ventricular failure02.05.02.001--Not Available
Lethargy17.02.04.003; 08.01.01.008; 19.04.04.004--
Leukaemia01.10.03.001; 16.01.03.0010.000556%
Leukocytosis01.02.01.0020.002398%
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Lip oedema07.05.04.004; 23.04.01.006; 10.01.05.0040.000799%Not Available
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.005--Not Available
Lipase increased13.05.01.0030.002398%
Livedo reticularis24.03.04.003; 23.06.05.001--Not Available
Liver disorder09.01.08.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Local swelling08.01.03.013--Not Available
Localised infection11.01.08.0060.001066%Not Available
Loss of consciousness17.02.04.004--Not Available
Lung disorder22.02.07.0010.006394%Not Available
Lung infiltration22.01.02.0040.001598%Not Available
Lymphadenopathy01.09.01.0020.005595%Not Available
Lymphangitis24.09.02.001; 11.01.15.001; 01.09.01.0050.000533%Not Available
Lymphocytosis01.02.01.0030.002398%Not Available
Lymphoma16.20.01.001; 01.12.01.0010.000347%Not Available
Lymphopenia01.02.02.002--Not Available
Macular oedema06.04.06.005--Not Available
Malabsorption14.02.01.004; 07.17.01.0010.000533%
Malaise08.01.01.003--
Malignant melanoma23.08.01.001; 16.03.01.001--Not Available
Mass08.03.05.0030.000799%Not Available
Melaena24.07.02.013; 07.12.02.004--Not Available
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