Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dasatinib
Drug ID BADD_D00589
Description Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
Indications and Usage For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
Marketing Status Prescription
ATC Code L01EA02
DrugBank ID DB01254
KEGG ID D03658
MeSH ID D000069439
PubChem ID 3062316
TTD Drug ID D0E6XR
NDC Product Code 63285-862; 63285-867; 0003-0855; 63285-863; 63285-866; 63285-865; 68554-0070; 54893-0015; 54893-0047; 0003-0857; 0003-0852; 0003-0527; 0003-0528; 76302-014; 50193-0524; 46708-891; 14778-1313; 62207-973; 63285-864; 0003-0524; 59651-468; 53104-7725
Synonyms Dasatinib | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | Sprycel | (18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | BMS 354825 | 354825, BMS | BMS354825 | BMS-354825
Chemical Information
Molecular Formula C22H26ClN7O2S
CAS Registry Number 302962-49-8
SMILES CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatitis C09.01.09.005; 11.05.06.004--Not Available
Hepatocellular injury09.01.07.008--Not Available
Hepatomegaly09.01.05.0010.000533%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.003730%Not Available
Hernia08.01.04.001--Not Available
Herpes simplex23.09.03.001; 11.05.02.0010.000799%Not Available
Herpes virus infection11.05.02.008--Not Available
Herpes zoster23.09.03.002; 11.05.02.003--
Hip fracture15.08.03.001; 12.04.01.001--
Hodgkin's disease16.31.01.001; 01.16.01.0010.000208%Not Available
Hydrocephalus17.07.01.0010.000799%
Hydrops foetalis18.03.02.0080.001865%Not Available
Hyperaesthesia17.02.06.0040.000799%Not Available
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.0030.001066%Not Available
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hyperchlorhydria07.11.03.0010.000533%Not Available
Hypercholesterolaemia14.08.01.001--Not Available
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperplasia08.03.04.0080.002931%Not Available
Hypersensitivity10.01.03.003--
Hypersensitivity vasculitis10.02.02.017; 01.01.04.008; 24.05.02.012; 23.06.02.005--Not Available
Hypersomnia19.02.05.001; 17.15.01.001--
Hypertension24.08.02.001--
Hypertensive encephalopathy24.08.05.001; 17.13.02.0020.000533%Not Available
Hypertensive heart disease02.01.04.001; 24.08.05.0020.000139%Not Available
Hyperthyroidism14.11.01.011; 05.02.02.001--
Hyperuricaemia14.09.01.003--
Hyphaema24.07.05.004; 12.01.04.007; 06.07.04.0010.000533%Not Available
Hypoaesthesia17.02.06.0230.009857%Not Available
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