| Drug Name |
Daptomycin |
| Drug ID |
BADD_D00581 |
| Description |
Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant _Staphylococcus aureus_ (MSSA/MRSA) and vancomycin-resistant Enterococci (VRE).[A231379, A231384, L32534] Chemically, daptomycin comprises 13 amino acids, including several non-standard and D-amino acids, with the C-terminal 10 amino acids forming an ester-linked ring and the N-terminal tryptophan covalently bonded to decanoic acid.[A231374, L32534] Daptomycin was first discovered in the early 1980s by researchers at Eli Lilly in soil samples from Mount Ararat in Turkey.[A231384] Early work on developing daptomycin was abandoned due to observed myopathy but was resumed in 1997 when Cubist Pharmaceuticals Inc. licensed daptomycin; it was found that a once-daily dosing scheme reduced side effects while retaining efficacy.[A231379]
Daptomycin was approved by the FDA on September 12, 2003, and is marketed under the name CUBICIN® by Cubist Pharmaceuticals LLC (Merck & Co.).[L32534] |
| Indications and Usage |
For the treatment of complicated skin and skin structure infections caused by susceptible strains of Gram-positive microorganisms. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
J01XX09 |
| DrugBank ID |
DB00080
|
| KEGG ID |
D01080
|
| MeSH ID |
D017576
|
| PubChem ID |
16134395
|
| TTD Drug ID |
D05HPI
|
| NDC Product Code |
71288-016; 0143-9378; 0703-0125; 0409-5933; 42513-0015; 16729-434; 67254-515; 73402-111; 31722-102; 0409-0122; 43598-413; 63323-585; 71288-017; 71839-107; 68225-082; 43598-476; 42513-0004; 72572-100; 69097-850; 0409-2757; 60977-145; 68225-052; 25021-174; 67919-012; 57885-0011; 25021-179; 72572-102; 69097-807; 70594-034; 51187-0002; 0409-0120; 67184-0549; 16714-892; 17337-0261; 60505-6229; 67457-813; 63323-871; 0781-3295; 71288-018; 16729-435; 63323-371; 68001-467; 68001-376; 55150-344; 70594-053; 71839-108; 67919-011 |
| Synonyms |
Daptomycin | Deptomycin | Cubicin | Daptomycin, 9-L beta-Aspartic Acid | Daptomycin, 9 L beta Aspartic Acid | LY-146032 | LY 146032 | LY146032 |
