Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dapagliflozin
Drug ID BADD_D00578
Description Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor indicated for managing diabetes mellitus type 2.[A6757] When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose resorption in the proximal tubule of the nephron and causing glycosuria.[A6757] Dapagliflozin was approved by the FDA on Jan 08, 2014.[L6034]
Indications and Usage Dapagliflozin is indicated for adjunct management of glycemic control in patients with type 2 diabetes mellitus, in combination with diet and exercise.
Marketing Status Prescription
ATC Code A10BK01
DrugBank ID DB06292
KEGG ID D08897
MeSH ID C529054
PubChem ID 9887712
TTD Drug ID D01TNW
NDC Product Code 17228-6205; 50090-3482; 14501-0028; 55154-6932; 59285-012; 66529-0003; 54921-621; 55111-987; 69037-0027; 65727-073; 12783-1428; 50090-3481; 0310-6205; 17228-6210; 12783-1427; 54921-620; 55154-6933; 46708-897; 66064-1029; 50193-1427; 59651-135; 0310-6210; 66039-933
Synonyms dapagliflozin | (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | Farxiga | Forxiga | 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol | BMS 512148 | BMS512148 | BMS-512148
Chemical Information
Molecular Formula C21H25ClO6
CAS Registry Number 461432-26-8
SMILES CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatitis09.01.07.0040.001206%Not Available
Hyperglycaemia14.06.02.002; 05.06.02.0020.004220%
Hyperhidrosis23.02.03.004; 08.01.03.0280.004823%
Hyperkalaemia14.05.03.0010.004220%
Hypernatraemia14.05.04.0010.001206%
Hyperphosphataemia14.04.03.007--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoglycaemia14.06.03.001; 05.06.03.0010.003618%
Hypomagnesaemia14.04.02.0010.001206%
Hyponatraemia14.05.04.002--
Hypotension24.06.03.002--
Hypothyroidism14.11.01.012; 05.02.03.0010.001206%
Hypovolaemia14.05.05.0020.003015%Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Influenza like illness08.01.03.0100.001809%
Insulin C-peptide decreased13.10.02.0060.001809%Not Available
Ketoacidosis14.01.01.0080.025323%Not Available
Ketonuria20.02.01.0090.003618%Not Available
Ketosis14.01.01.0010.002412%Not Available
Lactic acidosis14.01.01.002--Not Available
Lethargy08.01.01.008; 19.04.04.004; 17.02.04.003--
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.002412%Not Available
Lipase increased13.05.01.0030.001206%
Liver function test abnormal13.03.01.0130.001809%Not Available
Localised infection11.01.08.0060.003618%Not Available
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.003--
Metabolic acidosis14.01.01.0030.008441%Not Available
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