Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cytarabine hydrochloride
Drug ID BADD_D00561
Description A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Indications and Usage For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Marketing Status Prescription; Discontinued
ATC Code L01BC01
DrugBank ID DB00987
KEGG ID D03637
MeSH ID D003561
PubChem ID 6252
TTD Drug ID D07XSN
NDC Product Code 12848-1003; 61703-303; 61703-319; 71288-108; 71288-168; 55512-0026; 67457-455; 68083-343; 71288-109; 61703-305; 71288-169; 58623-0026; 70516-0163; 61703-304; 63323-120; 67457-452; 68083-337
Synonyms Cytarabine | Arabinosylcytosine | Cytosine Arabinoside | Arabinoside, Cytosine | Arabinofuranosylcytosine | Aracytidine | beta-Ara C | beta Ara C | Cytarabine Hydrochloride | Cytosar | Cytosar-U | Cytosar U | Ara-C | Ara C | Aracytine | Cytonal
Chemical Information
Molecular Formula C9H13N3O5.ClH
CAS Registry Number 69-74-9
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Leukoencephalopathy17.13.02.003--
Leukopenia01.02.02.001--Not Available
Lipase increased13.05.01.003--
Liver abscess11.01.18.001; 09.01.11.001--Not Available
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.003--
Memory impairment19.20.01.003; 17.03.02.003--
Meningism17.02.05.007--
Meningitis17.06.03.001; 11.01.03.001--
Monoplegia17.01.04.003--Not Available
Mucosal inflammation08.01.06.002--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Neck pain15.03.04.009--
Nervous system disorder17.02.10.001--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neurotoxicity17.02.10.002; 12.03.01.011--Not Available
Neutropenia01.02.03.004--Not Available
Non-cardiogenic pulmonary oedema24.03.08.004; 22.01.03.006--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral02.05.04.007; 14.05.06.011; 08.01.07.007--
Oesophageal ulcer07.04.05.002--
Oesophagitis07.08.05.001--
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
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