Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cyproterone
Drug ID BADD_D00554
Description An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
Indications and Usage For the palliative treatment of patients with advanced prostatic carcinoma.
Marketing Status Not Available
ATC Code G03HA01
DrugBank ID DB04839
KEGG ID D07766
MeSH ID D003534
PubChem ID 5284537
TTD Drug ID D06AEO
NDC Product Code 53104-7635; 46439-8720; 59010-000
Synonyms Cyproterone | Cyproterone, 1alpha,2 alpha,9 beta,10 alpha-Isomer
Chemical Information
Molecular Formula C22H27ClO3
CAS Registry Number 2098-66-0
SMILES CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C5CC5C34C)Cl)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Arrhythmia02.03.02.001--Not Available
Assisted fertilisation25.10.04.001--Not Available
Asthenia08.01.01.001--Not Available
Azoospermia21.03.03.001--
Bladder cancer20.03.04.001; 16.08.01.001--Not Available
Blood cortisol decreased13.10.09.004--Not Available
Blood creatinine increased13.13.01.004--
Breast tenderness21.05.05.004--Not Available
Cardiac failure02.05.01.001--
Coagulopathy01.01.02.001--Not Available
Constipation07.02.02.001--
Cough22.02.03.001--
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry skin23.03.03.001--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Dyspnoea exertional02.01.03.003; 22.02.01.005--Not Available
Ear disorder04.03.01.001--Not Available
Eczema23.03.04.006--
Encephalopathy17.13.02.001--
Extravasation08.01.03.008--Not Available
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.002--
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