Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cyanocobalamin
Drug ID BADD_D00542
Description Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. This vitamin is produced naturally by bacteria [A175276], and is necessary for DNA synthesis and cellular energy production. Vitamin B12 has many forms, including the cyano-, methyl-, deoxyadenosyl- and hydroxy-cobalamin forms. The _cyano_ form, is the most widely used form in supplements and prescription drugs [A175255], [FDA label]. Several pharmaceutical forms of cyanocobalamin have been developed, including the tablet, injection, and nasal spray forms [FDA label], [L5542], [L5545]. This drug was initially approved by the FDA in 1942 [FDA label].
Indications and Usage For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.
Marketing Status Prescription; Discontinued
ATC Code B03BA01
DrugBank ID DB00115
KEGG ID D00166
MeSH ID D014805
PubChem ID 5311498
TTD Drug ID D0FR6I
NDC Product Code 70069-172; 69680-113; 76420-111; 52584-399; 70529-293; 0143-9621; 72843-497; 0404-9840; 70069-171; 50396-7800; 70529-290; 40074-0013; 0517-0130; 63323-044; 76420-075; 70069-005; 72843-507; 50090-2709; 0143-9619; 68001-509; 63238-3700; 0517-0031; 69680-112; 55150-364; 51662-1394; 16729-533; 51927-1662; 0143-9620; 69680-121; 0517-0032; 49884-270; 0395-8140; 51662-1440; 68083-449; 81376-303; 82298-201; 51552-1045; 72843-487
Synonyms Vitamin B 12 | B 12, Vitamin | Vitamin B12 | B12, Vitamin | Cyanocobalamin | Cobalamins | Cobalamin | Eritron
Chemical Information
Molecular Formula C63H88CoN14O14P
CAS Registry Number 68-19-9
SMILES CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(= C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC (=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anxiety19.06.02.002--
Arthritis15.01.01.001--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Cardiac failure congestive02.05.01.002--Not Available
Coordination abnormal17.02.02.004--Not Available
Death08.04.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Gait disturbance17.02.05.016; 08.01.02.002--
Glossitis07.14.01.001--Not Available
Headache17.14.01.001--
Hypoaesthesia17.02.06.023--Not Available
Infection11.01.08.002--Not Available
Myalgia15.05.02.001--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Peripheral vascular disorder24.03.01.003--Not Available
Polycythaemia vera16.21.03.003; 01.13.03.002--Not Available
Pruritus23.03.12.001--
Pulmonary oedema22.01.03.003; 02.05.02.003--
Rash23.03.13.001--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Swelling08.01.03.015--Not Available
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