Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cosyntropin
Drug ID BADD_D00534
Description Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Tetracosactide exhibits the same activity as natural ACTH with regard to all its biological activities. The complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration.
Indications and Usage For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.
Marketing Status Prescription; Discontinued
ATC Code H01AA02
DrugBank ID DB01284
KEGG ID D00284
MeSH ID D003366
PubChem ID 16133802
TTD Drug ID D0W6LI
NDC Product Code 35207-0004; 51662-1567; 67457-227; 0548-5900; 50090-4547; 0781-3440
Synonyms Cosyntropin | ACTH 1-24 | Corticotropin (1-24)-Peptide | Corticotropin (1-24)-Tetracosapeptide | ACTH (1-24) | Tetracosactide | Tetracosactrin | Tetracosapeptide | 1-24-Corticotropin | 1-24-ACTH | Synthetic ACTH | ACTH, Synthetic | Cortrosyn | Cortosyn
Chemical Information
Molecular Formula C136H210N40O31S
CAS Registry Number 16960-16-0
SMILES CC(C)C(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N) C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=C(C=C2)O)C( =O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC5=CNC6=CC=CC=C65)NC( =O)C(CCCNC(=N)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC8=CNC=N8)NC(=O)C(CCC(=O)O)NC(=O)C (CCSC)NC(=O)C(CO)NC(=O)C(CC9=CC=C(C=C9)O)NC(=O)C(CO)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abscess11.01.08.001--Not Available
Adrenal haemorrhage24.07.01.023; 12.01.02.006; 05.01.03.002--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Bradycardia02.03.02.002--Not Available
Calcium deficiency05.04.02.004; 14.04.01.013--Not Available
Carbohydrate tolerance decreased13.02.02.003--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiac hypertrophy02.04.02.017--Not Available
Cataract subcapsular06.06.01.002--Not Available
Compression fracture15.08.02.004; 12.04.02.008--Not Available
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspnoea22.02.01.004; 02.01.03.002--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Embolism venous24.01.01.003--Not Available
Endocrine disorder05.09.01.001--Not Available
Erythema23.03.06.001--Not Available
Eye disorder06.08.03.001--Not Available
Feeling abnormal08.01.09.014--Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing08.01.03.025; 24.03.01.002; 23.06.05.003--
Gastrointestinal disorder07.11.01.001--Not Available
Glaucoma06.03.01.002--
Glucose tolerance impaired14.06.02.001; 05.06.02.001--
Haemoglobin13.01.05.018--Not Available
Headache17.14.01.001--
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