Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cortisone acetate
Drug ID BADD_D00533
Description Cortisone acetate was first isolate in 1935 and became more widely researched in 1949.[A226295] Since then, glucocorticoids such as cortisone acetate have been used to treat a number of inflammatory conditions such as endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, and gastrointestinal diseases and disorders.[A226300,L13203] Cortisone acetate was granted FDA approval on 13 June 1950.[L15107]
Indications and Usage For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders.
Marketing Status Prescription; Discontinued
ATC Code H02AB10; S01BA03
DrugBank ID DB01380
KEGG ID D00973
MeSH ID D003348
PubChem ID 5745
TTD Drug ID D0X4RS
NDC Product Code 0220-1554; 0143-1202; 0220-1553; 0143-9700; 64958-0025; 49452-2321; 0220-1550
Synonyms Cortisone | Cortisone Acetate | 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate | Cortone Acetate | Adreson
Chemical Information
Molecular Formula C23H30O6
CAS Registry Number 50-04-4
SMILES CC(=O)OCC(=O)C1(CCC2C1(CC(=O)C3C2CCC4=CC(=O)CCC34C)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin atrophy23.01.05.001--
Small intestinal perforation07.04.06.006--
Sodium retention14.05.04.003--Not Available
Spinal compression fracture12.04.04.001; 14.04.04.003; 15.08.05.004--Not Available
Tendon rupture15.07.01.008; 12.01.07.003--Not Available
Thrombophlebitis24.01.02.0010.026833%Not Available
Thrombophlebitis superficial24.01.02.0020.010733%
Unresponsive to stimuli17.02.05.031--Not Available
Urticaria23.04.02.001; 10.01.06.0010.010733%
Venous thrombosis24.01.01.0080.016100%Not Available
Vertigo17.02.12.002; 04.04.01.003--
Vomiting07.01.07.0030.016100%
Balance disorder17.02.02.0070.010733%Not Available
Restless legs syndrome17.02.07.008; 15.05.03.0120.021466%Not Available
Skin test negative13.06.04.002--Not Available
Lung infection22.07.01.008; 11.01.09.0080.010733%
Mental disorder19.07.01.0020.032199%Not Available
Drug intolerance08.06.01.0130.010733%Not Available
Psychotic disorder19.03.01.0020.010733%
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