| Drug Name |
Colestipol |
| Drug ID |
BADD_D00521 |
| Description |
Bile acid sequestrants like colestipol have been in use since the 1970s.[FDA Label, F4555, F4567, L6262] And even though such an agent may very well be useful in reducing elevated cholesterol levels and decreasing the risk for atherosclerotic vascular disease due to hypercholesterolemia, colestipol is still generally only employed as an adjunct therapy and the relatively physical nature of its pharmacological activity sometimes limits its usefulness.[FDA Label, F4555, F4567, L6262]
In particular, as colestipol's general mechanism of action ultimately results in the decreased absorption and enhanced secretion of bile acids and lipids in the feces, patients who take complicated medication regimens, experience constipation or biliary obstruction, etc. may not be good candidates for using the agent owing to its physical effects on the gut.[FDA Label, F4555, F4567, L6262]
Alternatively, colestipol predominantly elicits its activities within the gut environment because it undergoes little absorption and metabolism.[FDA Label, F4555, F4567, L6262] The resultant lack of systemic exposure consequently means the medication generally demonstrates very few adverse effects inside the body.[FDA Label, F4555, F4567, L6262] |
| Indications and Usage |
For use, as adjunctive therapy to diet, for the reduction of elevated serum total and LDL-C in patients with primary hypercholesterolemia (elevated LDL-C) who do not respond adequately to diet. |
| Marketing Status |
Prescription |
| ATC Code |
C10AC02 |
| DrugBank ID |
DB00375
|
| KEGG ID |
C06925
|
| MeSH ID |
D003084
|
| PubChem ID |
62816
|
| TTD Drug ID |
D0GJ8R
|
| NDC Product Code |
Not Available |
| Synonyms |
Colestipol | Colestipol Hydrochloride | Hydrochloride, Colestipol | Colestipol HCl | HCl, Colestipol | U-26,597 A | U 26,597 A | U26,597 A | Colestid |
