Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Codeine sulfate
Drug ID BADD_D00517
Description The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory functions. Opiates such as codeine are derived from the poppy plant, _Papaver somniferum_ (Papaveraceae).[A175096] Codeine is utilized as a central analgesic, sedative, hypnotic, antinociceptive, and antiperistaltic agent, and is also recommended in certain diseases with incessant coughing.[LABEL,A175096]
Indications and Usage For treatment and management of pain (systemic). It is also used as an antidiarrheal and as a cough suppressant.
Marketing Status Not Available
ATC Code R05DA04
DrugBank ID DB00318
KEGG ID D03580
MeSH ID D003061
PubChem ID 5359613
TTD Drug ID D03DIG
NDC Product Code 0527-1698; 0527-1699; 0406-1580; 0054-0245; 0054-0243; 0054-0244
Synonyms Codeine | Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)- | N-Methylmorphine | N Methylmorphine | Isocodeine | Codeine Phosphate | Ardinex
Chemical Information
Molecular Formula C36H44N2O10S
CAS Registry Number 1420-53-7
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O.CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C =C4)O.OS(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Depressed level of consciousnessCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Anxiety19.06.02.002--
Asthenia08.01.01.001--Not Available
Cardiac arrest02.03.04.001--
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dysphoria19.04.02.004--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Euphoric mood19.04.02.006--
Fatigue08.01.01.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Respiratory arrest22.02.01.009--Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Sedation17.02.04.005--Not Available
Shock24.06.02.002--Not Available
Somnolence19.02.05.003; 17.02.04.006--
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