ADReCS

Pharmaceutical Information

Drug Name	Clozapine
Drug ID	BADD_D00511
Description	A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage	For use in patients with treatment-resistant schizophrenia.
Marketing Status	Prescription; Discontinued
ATC Code	N05AH02
DrugBank ID	DB00363
KEGG ID	D00283
MeSH ID	D003024
PubChem ID	135398737
TTD Drug ID	D0Z1RV
NDC Product Code	57664-345; 0904-7088; 16729-141; 71554-025; 0093-3086; 51079-921; 55154-3568; 60687-404; 0378-3815; 51407-086; 0093-3087; 52817-601; 76072-1010; 0378-0972; 60687-548; 51862-274; 60429-989; 64374-004; 70518-3391; 12828-0072; 0378-0825; 60687-415; 53296-0033; 65862-846; 57664-241; 55154-8285; 57664-347; 65015-706; 60429-990; 51862-901; 0378-3813; 51407-085; 63552-062; 63629-2360; 69809-0126; 60687-426; 63629-2361; 72721-1725; 72721-1760; 0093-4404; 0904-7089; 67835-0028; 65862-847; 16729-142; 0378-0860; 57664-211; 51862-903; 0093-7772; 51862-273; 65862-844; 51079-749; 51079-922; 0093-5377; 0904-7087; 63629-2362; 65862-845; 70518-3357; 63552-063; 0093-5416; 69809-0130; 72721-1750; 51079-288; 72721-1770; 0093-4359; 0093-5419; 69809-0127; 0093-5376; 69809-0135; 63629-2359; 0378-0973; 73377-150; 51862-902; 0093-5417; 0093-4405; 51862-900
Synonyms	Clozapine \| Clozaril \| Leponex

Chemical Information

Molecular Formula	C18H19ClN4
CAS Registry Number	5786-21-0
SMILES	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure

ADR Related Proteins Induced by Drug

ADR Term	Protein Name	UniProt AC	TTD Target ID	PMID
Tardive dyskinesia	D(3) dopamine receptor	P35462	T02551	10821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesia	D(4) dopamine receptor	P21917	T24983	10821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesia	D(2) dopamine receptor	P14416	T67162	10821369; 10379516; 10893495; 9777180; 10889553

ADRs Induced by Drug

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Chronic obstructive pulmonary disease	22.03.01.007	0.154985%		Not Available
Chronic sinusitis	22.07.03.018; 11.01.13.016	0.005605%		Not Available
Circulatory collapse	24.06.02.001	0.201773%		Not Available
Clavicle fracture	15.08.03.010; 12.04.01.010	0.011210%		Not Available
Clostridium difficile colitis	11.02.02.004; 07.19.01.004	-	-	Not Available
Coagulopathy	01.01.02.001	-	-	Not Available
Cogwheel rigidity	17.01.05.001; 15.05.04.006	0.008407%		Not Available
Cold sweat	08.01.03.024; 23.02.03.002	-	-	Not Available
Colitis	07.08.01.001	0.067258%
Colitis ischaemic	24.04.08.012; 07.08.01.004	0.042036%		Not Available
Colitis ulcerative	10.02.01.004; 07.08.01.005	-	-	Not Available
Colon cancer	16.13.01.001; 07.21.01.001	0.011697%		Not Available
Coma	17.02.09.001	0.190563%		Not Available
Compartment syndrome	24.04.05.006; 15.05.05.005	-	-	Not Available
Completed suicide	19.12.01.001; 08.04.01.010	0.097231%		Not Available
Complex partial seizures	17.12.02.003	0.005605%		Not Available
Concussion	17.11.01.004; 12.01.10.005	-	-	Not Available
Conduction disorder	02.03.01.008	0.016814%
Confusional state	19.13.01.001; 17.02.03.005	-	-
Conjunctivitis	06.04.01.002; 11.01.06.012	-	-
Constipation	07.02.02.001	0.613726%
Corneal deposits	06.06.03.002	0.002193%		Not Available
Coronary artery disease	24.04.04.006; 02.02.01.001	-	-	Not Available
Coronary artery occlusion	24.04.04.013; 02.02.01.006	-	-	Not Available
Coronary artery stenosis	24.04.04.017; 02.02.01.010	-	-	Not Available
Coronary artery thrombosis	24.01.05.002; 02.02.01.007	0.002193%		Not Available
Cough	22.02.03.001	-	-
Creatinine renal clearance decreased	13.13.01.013	-	-	Not Available
Crohn's disease	07.08.01.015; 10.02.01.005	-	-	Not Available
Crying	19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.005	-	-	Not Available

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