Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Chronic lymphocytic leukaemia16.01.06.001; 01.10.06.0010.014674%Not Available
Chronic myeloid leukaemia16.01.07.001; 01.10.07.001--Not Available
Chronic obstructive pulmonary disease22.03.01.0070.159217%Not Available
Circulatory collapse24.06.02.0010.055274%Not Available
Claustrophobia19.06.03.0050.001223%Not Available
Cogwheel rigidity17.01.05.001; 15.05.04.0060.001834%Not Available
Colitis ischaemic24.04.08.012; 07.08.01.0040.012473%Not Available
Colon cancer16.13.01.001; 07.21.01.001--Not Available
Coma17.02.09.0010.067869%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.113115%Not Available
Compulsions19.06.05.0030.002446%Not Available
Conduction disorder02.03.01.0080.003669%
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.0010.216080%
Corneal deposits06.06.03.0020.001223%Not Available
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Coronary artery thrombosis24.01.05.002; 02.02.01.0070.002446%Not Available
Cough22.02.03.001--
Crepitations08.01.03.006--Not Available
Cyanosis02.11.04.004; 22.02.02.007; 23.06.04.005; 24.03.01.007--
Death08.04.01.0013.184343%
Decreased activity19.11.01.002; 08.01.01.0060.008193%Not Available
Decubitus ulcer23.03.11.0060.009416%Not Available
Defect conduction intraventricular02.03.01.0180.001223%Not Available
Delirium19.13.02.0010.086212%
Delusion19.10.01.0010.077897%
Delusional disorder, unspecified type19.03.03.0020.001834%Not Available
Dementia19.20.02.001; 17.03.01.0010.068358%Not Available
Dementia Alzheimer's type19.20.03.001; 17.03.06.001--Not Available
Depressed level of consciousness17.02.04.0020.049771%
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ADReCS-Target
Drug Name ADR Term Target
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