Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bundle branch block right02.03.01.0110.018954%Not Available
Burkitt's lymphoma16.28.04.001; 01.15.04.0010.004891%Not Available
Cachexia16.32.03.011; 14.03.02.001; 08.01.01.009--Not Available
Cardiac arrest02.03.04.0010.099541%
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiac tamponade02.06.01.001--
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiogenic shock24.06.02.006; 02.05.01.003--Not Available
Cardiomegaly02.04.02.0010.011617%Not Available
Cardiomyopathy02.04.01.0010.057475%Not Available
Cardiovascular disorder02.11.01.010; 24.03.02.009--Not Available
Cataplexy19.02.02.003; 17.15.01.003; 15.05.04.010--Not Available
Cataract subcapsular06.06.01.0020.001834%Not Available
Catatonia19.11.01.0010.073983%Not Available
Cerebral atrophy17.11.01.001--Not Available
Cerebral infarction17.08.01.004; 24.04.06.002--Not Available
Cerebrovascular disorder24.03.05.002; 17.08.02.002--Not Available
Cervix carcinoma21.06.02.001; 16.12.01.0010.006726%Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Chills08.01.09.001; 15.05.03.016--
Choking22.12.03.0030.048915%Not Available
Choking sensation22.12.03.004; 19.01.02.0020.003057%Not Available
Cholangitis09.02.01.002--Not Available
Cholecystitis09.03.01.001--
Cholecystitis acute09.03.01.003--Not Available
Cholestasis09.01.01.001--Not Available
Cholinergic syndrome17.05.01.002--Not Available
Choreoathetosis17.01.01.0030.002446%Not Available
Chronic hepatitis11.07.01.009; 09.01.07.0210.001223%Not Available
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene