Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clorazepic acid
Drug ID BADD_D00507
Description A water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions.
Indications and Usage For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal.
Marketing Status Prescription; Discontinued
ATC Code N05BA05
DrugBank ID DB00628
KEGG ID D00694
MeSH ID D003009
PubChem ID 2809
TTD Drug ID D0P3JU
NDC Product Code Not Available
Synonyms Clorazepate Dipotassium | Dipotassium Chlorazepate | 4306-CB | Chlorazepate | Clorazepate | Tranxene | Tranxilium | Clorazepic Acid | Clorazepate Monopotassium
Chemical Information
Molecular Formula C16H11ClN2O3
CAS Registry Number 23887-31-2
SMILES C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intestinal obstruction07.13.01.0020.001231%Not Available
Irritability19.04.02.013; 08.01.03.011--
Leukopenia01.02.02.0010.004718%Not Available
Malaise08.01.01.0030.007077%
Migraine24.03.05.003; 17.14.02.0010.004718%Not Available
Miosis17.02.11.002; 06.05.03.0030.004718%Not Available
Nervousness19.06.02.003--Not Available
Neuroleptic malignant syndrome17.05.02.003; 15.05.04.015; 12.03.01.003; 08.05.01.0050.004718%Not Available
Neutropenia01.02.03.0040.004718%Not Available
Pancreatitis acute07.18.01.0020.004718%Not Available
Pneumonia aspiration22.01.01.0050.001231%Not Available
Pruritus23.03.12.0010.004718%
Pyrexia08.05.02.0030.004718%
Rash23.03.13.001--Not Available
Rash erythematous23.03.06.0030.004718%Not Available
Rash maculo-papular23.03.13.0040.004718%
Rhabdomyolysis15.05.05.0020.007077%
Seizure17.12.03.0010.021232%
Somnolence19.02.05.003; 17.02.04.0060.011795%
Tachycardia02.03.02.0070.004718%Not Available
Tension19.06.02.005--Not Available
Tremor17.01.06.002--
Urinary tract infection20.08.02.001; 11.01.14.0040.004718%
Vision blurred06.02.06.007; 17.17.01.010--
Bacterial sepsis11.02.01.0290.004718%Not Available
Abdominal neoplasm16.16.02.002; 07.21.04.0010.004718%Not Available
Neurological decompensation17.02.05.0300.007077%Not Available
Acute kidney injury20.01.03.0160.007077%
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