Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clopidogrel
Drug ID BADD_D00504
Description Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213]
Indications and Usage For the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
Marketing Status Prescription; Discontinued
ATC Code B01AC04
DrugBank ID DB00758
KEGG ID D07729
MeSH ID D000077144
PubChem ID 60606
TTD Drug ID D0N0TZ
NDC Product Code 65977-0037; 0093-7314; 16729-218; 42543-713; 71335-1409; 42543-714; 65162-414; 68788-7645; 52605-083; 50090-5781; 50090-4918; 70518-0400; 61919-737; 52605-082; 63653-1171; 0024-1332; 63187-362; 70934-708; 61919-007; 33342-060; 68071-1578; 70771-1062; 68071-4138; 71335-0581; 63629-4728; 16729-219; 63653-1332; 0024-1171; 72578-012
Synonyms Clopidogrel | SC 25989C | SC 25990C | SR 25989 | Clopidogrel-Mepha | Clopidogrel Mepha | Clopidogrel Sandoz | Iscover | Clopidogrel Napadisilate | Clopidogrel Hydrochloride | PCR 4099 | PCR-4099 | Clopidogrel Besylate | Clopidogrel Besilate | Clopidogrel, (+)(S)-isomer | Plavix | Clopidogrel Bisulfate
Chemical Information
Molecular Formula C16H16ClNO2S
CAS Registry Number 113665-84-2
SMILES COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiogenic shock24.06.02.006; 02.05.01.0030.000358%Not Available
Cardiomegaly02.04.02.0010.000147%Not Available
Cardiomyopathy02.04.01.001--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Carotid artery stenosis24.04.06.001; 17.08.02.0010.000245%Not Available
Carotid artery thrombosis24.01.04.007; 17.08.01.0250.000077%Not Available
Cataract06.06.01.0010.000392%
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebellar syndrome17.02.02.0020.000147%Not Available
Cerebral artery embolism24.01.04.001; 17.08.01.0010.000026%Not Available
Cerebral artery occlusion17.08.01.028; 24.04.06.0200.000098%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.002035%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.003287%Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.0050.000736%
Cerebrovascular accident24.03.05.001; 17.08.01.0070.003679%
Cerebrovascular disorder24.03.05.002; 17.08.02.0020.000051%Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.001276%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.003581%Not Available
Chest X-ray abnormal13.19.02.0010.000098%Not Available
Chills08.01.09.001; 15.05.03.016--
Choking22.02.05.0010.000245%Not Available
Choking sensation22.02.05.002; 19.01.02.0020.000392%Not Available
Cholangitis09.02.01.0020.000196%Not Available
Cholecystitis09.03.01.0010.000245%
Cholecystitis acute09.03.01.0030.000392%Not Available
Cholelithiasis09.03.01.0020.000294%Not Available
Cholestasis09.01.01.0010.000981%Not Available
Choroidal detachment12.01.04.006; 06.09.01.0030.000196%Not Available
Chromaturia20.02.01.0020.000589%
Chronic obstructive pulmonary disease22.03.01.007--Not Available
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