Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clonidine
Drug ID BADD_D00502
Description Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.[L7237]
Indications and Usage Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications.[L7237,L7240] A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient.[L7243] An extended release tablet of clonidine is indicated for the treatment of ADHD either alone or in combination with other medications.[L7246] Clonidine is also used for the diagnosis of pheochromocytoma,[A180565] treatment of nicotine dependance,[A180568] and opiate withdrawal.[A180571]
Marketing Status approved
ATC Code C02AC01; N02CX02; S01EA04
DrugBank ID DB00575
KEGG ID D00281
MeSH ID D003000
PubChem ID 2803
TTD Drug ID D03SKR
NDC Product Code 51862-454; 0597-0033; 69988-0033; 51862-453; 0378-0872; 0591-3510; 0378-0871; 0378-0873; 0597-0032; 0591-3509; 39822-2010; 69238-1426; 50742-247; 0591-3508; 39822-2000; 68134-603; 71511-503; 0597-0031; 51862-455
UNII MN3L5RMN02
Synonyms Clonidine | Klofenil | Clofenil | Chlophazolin | Clonidine Dihydrochloride | Dihydrochloride, Clonidine | Clonidine Hydrochloride | Hydrochloride, Clonidine | Clonidine Monohydrochloride | Monohydrochloride, Clonidine | Clonidine Monohydrobromide | Monohydrobromide, Clonidine | ST-155 | ST 155 | ST155 | Gemiton | Hemiton | Isoglaucon | Klofelin | Clofelin | Clopheline | M-5041T | M 5041T | M5041T | Catapres | Catapresan | Catapressan | Dixarit
Chemical Information
Molecular Formula C9H9Cl2N3
CAS Registry Number 4205-90-7
SMILES C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hyperaesthesia23.03.03.080; 17.02.06.004--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.0020.000045%
Hyperhidrosis08.01.03.028; 23.02.03.0040.000045%
Hypersensitivity10.01.03.003--
Hypertension24.08.02.0010.000677%
Hypertensive crisis24.08.01.0010.000136%Not Available
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypokinesia17.01.02.009--Not Available
Hypotension24.06.03.0020.000959%
Hypotonia17.05.02.002; 15.05.04.0080.000068%Not Available
Hypoventilation22.02.01.007--Not Available
Hypoxia22.02.02.003--
Ileus07.13.01.001--
Infection11.01.08.002--Not Available
Influenza like illness08.01.03.010--
Injection site bruising24.07.06.017; 23.03.11.015; 12.07.03.042; 08.02.03.042--Not Available
Insomnia17.15.03.002; 19.02.01.0020.000145%
Instillation site pain12.07.01.008; 08.02.01.008--Not Available
Irritability19.04.02.013; 08.01.03.0110.000154%
Lacrimation decreased06.08.02.007--Not Available
Left ventricular failure02.05.02.0010.000227%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.000191%
Libido decreased21.03.02.005; 19.08.03.001--
Liver function test abnormal13.03.04.030--Not Available
Loss of consciousness17.02.04.0040.000136%Not Available
Loss of libido19.08.03.003--Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.002--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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