Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clomiphene
Drug ID BADD_D00497
Description A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Indications and Usage Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation.
Marketing Status Prescription; Discontinued
ATC Code G03GB02
DrugBank ID DB00882
KEGG ID D07726
MeSH ID D002996
PubChem ID 1548953
TTD Drug ID D0CT9Y
NDC Product Code Not Available
Synonyms Clomiphene | Clomifene | Chloramiphene | Clomifen | Clomiphene Citrate | Citrate, Clomiphene | Clomiphene Hydrochloride | Hydrochloride, Clomiphene | Serophene | Gravosan | Klostilbegit | Clostilbegit | Clomid | Clomide | Dyneric
Chemical Information
Molecular Formula C26H28ClNO
CAS Registry Number 15690-57-0
SMILES CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Transaminases increased13.03.01.015--Not Available
Neuroectodermal neoplasm17.20.01.006; 16.30.01.006--Not Available
Adnexa uteri pain21.07.04.006--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Abdominal symptom07.01.06.007--Not Available
Embolism24.01.01.009--
Gastrointestinal malformation07.11.04.004; 03.04.07.002--Not Available
Psychotic disorder19.03.01.002--
Hepatoblastoma16.07.04.001; 09.04.02.003--Not Available
Skull malformation15.11.02.003; 03.11.02.003--Not Available
Arterial occlusive disease24.04.02.021--Not Available
Pelvic discomfort21.10.01.012; 20.02.03.012; 07.01.06.020--Not Available
Tibial torsion15.11.07.009; 03.11.07.009--Not Available
Renal aplasia20.01.02.001; 03.06.01.002--Not Available
Ovarian haemorrhage24.07.03.009; 21.11.02.006--
Hepatic angiosarcoma24.03.06.007; 16.07.02.003; 09.04.02.007--Not Available
Cloacal exstrophy03.03.02.004; 21.15.02.003; 20.08.03.004; 07.11.04.005--Not Available
Cytogenetic abnormality03.12.02.001--Not Available
Renal cell carcinoma20.01.04.003; 16.08.02.002--Not Available
Intellectual disability19.21.06.001; 17.03.07.001--Not Available
Adnexal torsion21.11.02.012--Not Available
Hepatic cancer16.07.02.004; 09.04.02.008--Not Available
Hepatocellular carcinoma16.07.02.005; 09.04.02.010--Not Available
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