Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clobazam
Drug ID BADD_D00488
Description Clobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.
Indications and Usage For treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.
Marketing Status Prescription; Discontinued
ATC Code N05BA09
DrugBank ID DB00349
KEGG ID D01253
MeSH ID D000078306
PubChem ID 2789
TTD Drug ID D0S9MC
NDC Product Code 67386-313; 64330-110; 69766-016; 51672-4203; 0054-0561; 11014-0115; 82348-103; 72606-003; 69452-115; 42571-316; 67877-666; 51672-4210; 70710-1326; 51672-4202; 68180-157; 16714-087; 69238-1305; 51672-4227; 67877-665; 11014-0114; 69037-0009; 13632-313; 66689-058; 59651-401; 69238-1535; 0832-0585; 65085-0054; 70771-1441; 70710-1325; 47621-047; 67877-658; 69539-153; 67386-314; 68180-156; 0527-1681; 60687-423; 12828-0084; 68180-158; 31722-639; 31722-640; 10094-205; 69539-154; 70771-1440; 0832-0581; 16714-887; 72606-004; 0378-8043; 0832-0580; 42571-315; 69452-114; 0781-8013; 0054-0526; 51991-900; 51991-901; 42571-308; 0527-1682; 48087-0094; 10094-210; 0527-5301; 69238-1306; 69452-116; 16714-888; 67386-315; 0781-8014; 10094-220; 31722-641; 0054-0527; 48087-0117
Synonyms Clobazam | Urbanyl | Onfi | 1-Phenyl-5-methyl-8-chloro-1,2,4,5- tetrahydro-2,4-diketo-3H-1,5-benzodiazepine | HR 376 | LM-2717 | LM 2717 | LM2717 | Frisium
Chemical Information
Molecular Formula C16H13ClN2O2
CAS Registry Number 22316-47-8
SMILES CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Death08.04.01.001--
Decreased activity19.11.01.002; 08.01.01.0060.000602%Not Available
Delayed recovery from anaesthesia17.02.04.011; 12.02.12.0030.000602%Not Available
Delirium19.13.02.001--
Delusion19.10.01.001--
Dependence19.07.02.003--Not Available
Depressed level of consciousness17.02.04.0020.001204%
Depressed mood19.15.02.0010.000602%Not Available
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Disorientation19.13.01.002; 17.02.05.0150.000903%Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.001505%
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Drooling17.02.05.0050.001505%Not Available
Drug abuse19.07.02.0100.000471%Not Available
Drug dependence19.07.02.009--Not Available
Drug withdrawal convulsions17.12.03.016; 08.06.02.0030.008729%Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.004--Not Available
Dry mouth07.06.01.002--
Dysarthria19.19.03.001; 17.02.08.0010.000602%
Dyskinesia17.01.02.0060.001505%
Dysphagia07.01.06.0030.002107%
Dyspnoea22.02.01.004; 02.01.03.002--
Electroencephalogram abnormal13.07.03.0010.000602%Not Available
Encephalopathy17.13.02.0010.001505%
Eosinophilia01.02.04.001--
Epilepsy17.12.03.0020.001806%Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
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