Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clemastine fumarate
Drug ID BADD_D00481
Description An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Indications and Usage For the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus and acrimation. Also for the management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Used as self-medication for temporary relief of symptoms associated with the common cold.
Marketing Status Prescription; OTC; Discontinued
ATC Code D04AA14; R06AA04
DrugBank ID DB00283
KEGG ID D00666
MeSH ID D002974
PubChem ID 5281069
TTD Drug ID D0C5XC
NDC Product Code 73377-061; 0093-0308; 73308-358; 55152-001; 54838-514
Synonyms Clemastine | Mecloprodin | 2-(2-(1-(4-Chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine | Meclastine | Tavist | Tavegyl | Clemastine Fumarate | HS-592 | HS 592 | HS592
Chemical Information
Molecular Formula C25H30ClNO5
CAS Registry Number 14976-57-9
SMILES CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C.C(=CC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.001--
Agranulocytosis01.02.03.001--Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Asthenia08.01.01.001--Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chills15.05.03.016; 08.01.09.001--
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Conversion disorder19.24.01.001--Not Available
Coordination abnormal17.02.02.004--Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015--Not Available
Dry mouth07.06.01.002--
Dry throat22.02.05.004; 07.06.01.005--Not Available
Dyspepsia07.01.02.001--
Dysuria20.02.02.002--
Euphoric mood19.04.02.006--
Extrasystoles02.03.02.003--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypotension24.06.03.002--
Insomnia17.15.03.002; 19.02.01.002--
Irritability19.04.02.013; 08.01.03.011--
Labyrinthitis11.01.05.002; 04.04.03.001--Not Available
Menstruation irregular21.01.01.005; 05.05.01.008--
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