Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cladribine
Drug ID BADD_D00479
Description An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Indications and Usage For the treatment of active hairy cell leukemia (leukemic reticuloendotheliosis) as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease-related symptoms. Also used as an alternative agent for the treatment of chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin's lymphoma, and cutaneous T-cell lymphoma.
Marketing Status Prescription; Discontinued
ATC Code L01BB04; L04AA40
DrugBank ID DB00242
KEGG ID D01370
MeSH ID D017338
PubChem ID 20279
TTD Drug ID D05GJW
NDC Product Code 65129-1260; 67457-450; 63323-140; 42658-010; 54893-0115; 59605-3006; 58623-0037; 12502-4912; 0143-9871; 12502-5406; 44087-4000
Synonyms Cladribine | 2-Chlorodeoxyadenosine | 2-Chloro-2'-deoxyadenosine | 2'-Deoxy-2-chloroadenosine | Leustatin
Chemical Information
Molecular Formula C10H12ClN5O3
CAS Registry Number 4291-63-8
SMILES C1C(C(OC1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.0010.001825%
Myasthenia gravis17.05.04.001; 15.05.08.001; 10.04.05.0010.000730%
Myelodysplastic syndrome16.01.04.001; 01.10.04.0010.000190%
Myocardial ischaemia02.02.02.008; 24.04.04.010--Not Available
Nasopharyngitis11.01.13.002; 22.07.03.0020.001095%Not Available
Nausea07.01.07.0010.006204%
Neoplasm16.16.02.001--Not Available
Neoplasm malignant16.16.01.001--Not Available
Nervous system disorder17.02.10.001--Not Available
Neuritis17.09.03.001--Not Available
Neurotoxicity17.02.10.002; 12.03.01.0110.001095%Not Available
Neutropenia01.02.03.0040.002919%Not Available
Neutrophil count decreased13.01.06.0100.000730%
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Opportunistic infection11.01.08.007--Not Available
Oral candidiasis07.05.07.001; 11.03.03.004--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pain of skin23.03.03.003--
Pancytopenia01.03.03.0030.001095%Not Available
Paraesthesia17.02.06.0050.001825%
Paralysis17.01.04.004--Not Available
Paraparesis17.01.04.006--Not Available
Peripheral motor neuropathy17.09.03.004--
Peripheral sensory neuropathy17.09.03.005--
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Phlebitis24.05.03.001; 12.02.01.002--
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