Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cladribine
Drug ID BADD_D00479
Description An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Indications and Usage For the treatment of active hairy cell leukemia (leukemic reticuloendotheliosis) as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease-related symptoms. Also used as an alternative agent for the treatment of chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin's lymphoma, and cutaneous T-cell lymphoma.
Marketing Status Prescription; Discontinued
ATC Code L01BB04; L04AA40
DrugBank ID DB00242
KEGG ID D01370
MeSH ID D017338
PubChem ID 20279
TTD Drug ID D05GJW
NDC Product Code 65129-1260; 67457-450; 63323-140; 42658-010; 54893-0115; 59605-3006; 58623-0037; 12502-4912; 0143-9871; 12502-5406; 44087-4000
Synonyms Cladribine | 2-Chlorodeoxyadenosine | 2-Chloro-2'-deoxyadenosine | 2'-Deoxy-2-chloroadenosine | Leustatin
Chemical Information
Molecular Formula C10H12ClN5O3
CAS Registry Number 4291-63-8
SMILES C1C(C(OC1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dyspnoea exertional22.02.01.005; 02.01.03.003--Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Eosinophilia01.02.04.001--
Epilepsy17.12.03.002--Not Available
Epistaxis22.04.03.001; 24.07.01.005--
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Extravasation08.01.03.008--Not Available
Eye disorder06.08.03.001--Not Available
Fatigue08.01.01.0020.004014%
Febrile neutropenia01.02.03.002; 08.05.02.0040.001095%
Feeling abnormal08.01.09.0140.001095%Not Available
Flatulence07.01.04.002--
Fungal infection11.03.05.001--Not Available
Gait disturbance17.02.05.016; 08.01.02.0020.000190%
Gamma-glutamyltransferase increased13.03.01.0110.001460%
Gastric cancer16.13.03.001; 07.21.02.0010.000190%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Graft versus host disease12.02.09.001; 10.02.01.027--Not Available
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.0030.000730%Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.0010.005474%
Hepatic failure09.01.03.002--
Hepatotoxicity09.01.07.009; 12.03.01.0080.000730%Not Available
Herpes virus infection11.05.02.008--Not Available
Herpes zoster23.09.03.002; 11.05.02.0030.002189%
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.0030.000730%
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