Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Citalopram
Drug ID BADD_D00475
Description Citalopram belongs to a class of antidepressant agents known as selective _serotonin-reuptake inhibitors_ (SSRIs) and is widely used to treat the symptoms of depression. Its chemical structure is unrelated to that of other SSRIs or of tricyclic, tetracyclic, or other prescribed antidepressants [FDA label]. Citalopram is also known as _Celexa_, and available in tablet and solution forms [FDA label]. This drug was initially approved by the FDA in 1998 [L5230].
Indications and Usage For the treatment of depression. Off-label indications include: treatment of mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy [FDA label].
Marketing Status Prescription
ATC Code N06AB04
DrugBank ID DB00215
KEGG ID D07704
MeSH ID D015283
PubChem ID 2771
TTD Drug ID D0Y5DO
NDC Product Code 69097-823; 42806-020; 70518-0561; 43063-385; 43353-112; 70518-2228; 65162-054; 67046-102; 71610-092; 0456-4020; 50090-5170; 69097-824; 68788-7899; 70518-2617; 43063-063; 70934-539; 65162-052; 54458-980; 69097-822; 70518-2553; 0054-0062; 52427-691; 60429-174; 67046-106; 76282-629; 61919-390; 76282-628; 50090-5172; 54458-889; 70518-2601; 70518-2671; 54458-981; 0378-6233; 71335-0541; 60429-173; 71610-412; 63850-3616; 65162-053; 0378-6231; 0456-4010; 42806-021; 76282-206; 68071-3034; 67046-101; 70518-0449; 60429-175; 70934-397; 43353-208; 50090-5175; 63629-6761; 0456-4040; 61919-389; 76282-208; 71610-422; 80425-0093; 76282-207; 0378-6232; 43353-091; 42806-019
Synonyms Citalopram | Cytalopram | Citalopram Hydrobromide | Lu-10-171 | Lu10171 | Seropram | Celexa
Chemical Information
Molecular Formula C20H21FN2O
CAS Registry Number 59729-33-8
SMILES CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.000542%
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.0030.001458%
Abnormal dreams19.02.03.001; 17.15.02.0010.000875%Not Available
Abnormal faeces07.01.03.0010.000125%Not Available
Abnormal weight gain14.03.02.0100.000054%Not Available
Abortion18.01.01.0010.000083%Not Available
Abortion missed18.01.01.0020.000250%Not Available
Abortion spontaneous18.01.04.001--Not Available
Abscess11.01.08.001--Not Available
Accommodation disorder06.02.04.0010.000292%Not Available
Acidosis14.01.03.0020.000333%
Acne23.02.01.001--Not Available
Acromegaly05.03.01.005; 24.08.04.004; 15.03.01.018; 14.11.01.0290.000083%Not Available
Acute hepatic failure09.01.03.0010.000054%Not Available
Acute psychosis19.03.01.0010.000083%Not Available
Acute respiratory distress syndrome22.01.03.0010.000196%
Acute respiratory failure22.02.06.001; 14.01.04.0040.000065%Not Available
Affective disorder19.04.04.0010.000250%Not Available
Ageusia17.02.07.001; 07.14.03.0030.000333%Not Available
Aggression19.05.01.0010.001750%Not Available
Agitation17.02.05.012; 19.06.02.0010.002666%
Agitation neonatal18.04.04.002; 17.02.05.028; 19.06.02.0070.000708%Not Available
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.0020.000625%
Akinesia17.01.02.0030.000083%Not Available
Alanine aminotransferase increased13.03.01.003--
Alcohol abuse19.07.02.0070.000583%Not Available
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