Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cisplatin
Drug ID BADD_D00474
Description Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Indications and Usage For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Marketing Status approved
ATC Code L01XA01
DrugBank ID DB00515
KEGG ID D00275
MeSH ID D002945
PubChem ID 5702198
TTD Drug ID D0U5HU
NDC Product Code 16729-288; 25021-253; 0143-9505; 68554-0077; 0143-9504; 68001-283; 44567-509; 50711-0001; 44567-510; 63323-103; 0703-5747; 0703-5748; 44567-530; 60505-6277; 68083-163; 44567-511; 49452-2078; 54875-0001; 67184-0010; 68083-162; 70860-206; 49812-0009; 72659-864
UNII Q20Q21Q62J
Synonyms Cisplatin | cis-Diamminedichloroplatinum(II) | Platinum Diamminodichloride | Diamminodichloride, Platinum | cis-Platinum | cis Platinum | Dichlorodiammineplatinum | cis-Diamminedichloroplatinum | cis Diamminedichloroplatinum | cis-Dichlorodiammineplatinum(II) | NSC-119875 | Platino | Platinol | Biocisplatinum | Platidiam
Chemical Information
Molecular Formula PtCl2(NH3)2
CAS Registry Number 15663-27-1
SMILES N.N.Cl[Pt]Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cerebral ischaemia24.04.06.003; 17.08.01.0050.000168%
Cerebral venous thrombosis24.01.04.005; 17.08.03.0020.000504%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cervix carcinoma21.06.02.001; 16.12.01.0010.000168%Not Available
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.0090.000884%Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.12.02.0030.002149%Not Available
Chills15.05.03.016; 08.01.09.0010.003313%
Choking22.12.03.0030.000280%Not Available
Choking sensation22.12.03.004; 19.01.02.0020.000168%Not Available
Cholangitis09.02.01.0020.000280%Not Available
Cholecystitis09.03.01.0010.000280%
Cholelithiasis09.03.01.0020.000168%Not Available
Chromatopsia06.02.05.001--Not Available
Chronic myeloid leukaemia16.01.07.001; 01.10.07.0010.000112%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.000526%Not Available
Circulatory collapse24.06.02.0010.000280%Not Available
Coagulopathy01.01.02.0010.000168%Not Available
Cold sweat23.02.03.002; 08.01.03.0240.000112%Not Available
Colitis07.08.01.0010.000336%
Colitis ischaemic24.04.08.012; 07.08.01.0040.000112%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctival haemorrhage24.07.05.001; 06.07.01.0010.000168%Not Available
Constipation07.02.02.0010.002709%
Coordination abnormal17.02.02.0040.000112%Not Available
Coronary artery thrombosis24.01.05.002; 02.02.01.0070.000504%Not Available
Cough22.02.03.0010.003235%
Cyanosis02.11.04.004; 24.03.01.007; 22.02.02.007; 23.06.04.0050.000280%
Deafness04.02.01.0010.001220%Not Available
Deafness neurosensory17.04.07.001; 04.02.01.0020.000783%Not Available
Decreased activity08.01.01.006; 19.11.01.0020.000168%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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