ADReCS

Pharmaceutical Information

Drug Name	Cisplatin
Drug ID	BADD_D00474
Description	Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Indications and Usage	For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Marketing Status	approved
ATC Code	L01XA01
DrugBank ID	DB00515
KEGG ID	D00275
MeSH ID	D002945
PubChem ID	5702198
TTD Drug ID	D0U5HU
NDC Product Code	16729-288; 25021-253; 0143-9505; 68554-0077; 0143-9504; 68001-283; 44567-509; 50711-0001; 44567-510; 63323-103; 0703-5747; 0703-5748; 44567-530; 60505-6277; 68083-163; 44567-511; 49452-2078; 54875-0001; 67184-0010; 68083-162; 70860-206; 49812-0009; 72659-864
UNII	Q20Q21Q62J
Synonyms	Cisplatin \| cis-Diamminedichloroplatinum(II) \| Platinum Diamminodichloride \| Diamminodichloride, Platinum \| cis-Platinum \| cis Platinum \| Dichlorodiammineplatinum \| cis-Diamminedichloroplatinum \| cis Diamminedichloroplatinum \| cis-Dichlorodiammineplatinum(II) \| NSC-119875 \| Platino \| Platinol \| Biocisplatinum \| Platidiam

Chemical Information

Molecular Formula	PtCl2(NH3)2
CAS Registry Number	15663-27-1
SMILES	N.N.Cl[Pt]Cl
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Skin warm	23.03.03.014	0.000492%		Not Available
Small cell lung cancer	16.19.08.003; 22.08.01.013	0.000112%		Not Available
Small intestinal obstruction	07.13.06.001	0.000336%
Small intestinal perforation	07.04.06.006	0.000168%
Speech disorder	22.12.03.027; 19.19.02.002; 17.02.08.003	0.000392%		Not Available
Splenic infarction	24.04.08.024; 01.09.02.004	0.000112%		Not Available
Sputum discoloured	22.02.03.010	0.000224%		Not Available
Squamous cell carcinoma	16.16.01.002	0.000112%		Not Available
Stomatitis	07.05.06.005	0.003515%
Stridor	22.04.02.003	0.000168%
Subarachnoid haemorrhage	17.08.01.010; 12.01.10.011; 24.07.04.004	0.000168%		Not Available
Sudden death	02.03.04.013; 08.04.01.003	0.000112%
Superior sagittal sinus thrombosis	24.01.04.004; 17.08.03.001	0.000224%		Not Available
Swelling	08.01.03.015	0.000940%		Not Available
Swollen tongue	23.04.01.014; 10.01.05.015; 07.14.02.003	0.000280%		Not Available
Syncope	02.11.04.015; 24.06.02.012; 17.02.04.008	0.001735%
Tachycardia	02.03.02.007	0.002462%		Not Available
Tenderness	08.01.08.005	0.000246%		Not Available
Tetany	15.05.03.013; 14.04.01.005; 05.04.02.003	-	-	Not Available
Throat tightness	22.12.03.031; 19.01.02.005	0.000548%		Not Available
Thrombocytopenia	01.08.01.002	0.007331%		Not Available
Thrombophlebitis	24.01.02.001	0.000168%		Not Available
Thrombotic microangiopathy	24.01.01.013; 20.01.07.004; 01.01.02.006	0.000448%		Not Available
Thrombotic thrombocytopenic purpura	23.06.01.011; 24.07.06.014; 01.08.01.005	0.000280%
Tinnitus	17.04.07.004; 04.04.01.002	0.001970%
Tongue oedema	23.04.01.009; 10.01.05.008; 07.14.02.007	0.000224%		Not Available
Tongue ulceration	07.14.01.003	0.000168%		Not Available
Toxic epidermal necrolysis	23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006	0.000168%
Transverse sinus thrombosis	24.01.04.013; 17.08.03.004	0.000168%		Not Available
Trismus	17.01.03.004; 15.05.04.004	0.000168%

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