Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cisatracurium besylate
Drug ID BADD_D00473
Description Cisatracurium is a nondepolarizing skeletal muscle relaxant for intravenous administration. Cisatracurium acts on cholinergic receptors, blocking neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors such as neostigmine. The neuromuscular block produced by cisatracurium besylate is readily antagonized by anticholinesterase agents once recovery has started. As with other nondepolarizing neuromuscular blocking agents, the more profound the neuromuscular block at the time of reversal, the longer the time required for recovery of neuromuscular function. Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action.
Indications and Usage For inpatients and outpatients as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation in the ICU.
Marketing Status Prescription
ATC Code M03AC11
DrugBank ID DB00565
KEGG ID D00759
MeSH ID C101584
PubChem ID 62886
NDC Product Code 0781-3153; 70710-1533; 58175-0541; 0781-3150; 40016-007; 70710-1532; 0409-3670; 70069-161; 0409-1103; 55150-284; 53183-4014; 0074-4378; 0703-2033; 71288-720; 70069-151; 63323-416; 72785-0009; 70069-141; 0409-5547; 0409-1208; 72785-0008; 0409-1098; 0074-4382; 57884-0018; 55150-286; 0703-2056; 72785-0011; 0074-4380; 43798-462; 0703-2045; 24584-1112; 0781-3152; 71288-712; 25021-668; 63323-418; 25021-669; 17404-1024; 70710-1534; 24584-1110; 25021-670; 71288-714; 0409-7083; 24584-1111; 71288-713; 63323-417
Synonyms cisatracurium | cisatracurium besylate | cisatracurium besilate | Nimbex | 51W89
Chemical Information
Molecular Formula C65H82N2O18S2
CAS Registry Number 96946-42-8
SMILES C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N+]4(CC C5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)[O-].C1=CC=C(C =C1)S(=O)(=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic shock24.06.02.004; Available
Anaphylactoid reaction24.06.03.007; Available
Bradycardia02.03.02.002--Not Available
Dermatitis23.03.04.002--Not Available
Muscular weakness15.05.06.001;
Myopathy15.05.05.001--Not Available
Neuromuscular block prolonged17.05.04.005; Available
Neuromuscular blockade17.05.04.003--Not Available
Rash23.03.13.001--Not Available
Histamine abnormal13.09.02.002--Not Available
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