Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cilostazol
Drug ID BADD_D00466
Description Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both primary and secondary aggregation and reducing calcium-induced contractions.
Indications and Usage For the reduction of symptoms of intermittent claudication (pain in the legs that occurs with walking and disappears with rest).
Marketing Status Prescription; Discontinued
ATC Code B01AC23
DrugBank ID DB01166
KEGG ID D01896
MeSH ID D000077407
PubChem ID 2754
TTD Drug ID D03VPC
NDC Product Code 46438-0632; 70518-2208; 72189-116; 66039-113; 0185-0223; 71610-037; 0093-2064; 0093-2065; 60505-2521; 70518-2714; 46438-0633; 50090-5329; 0054-0028; 50268-177; 70436-157; 63629-8796; 70518-2200; 0054-0044; 50268-176; 42291-453; 58175-0379; 70436-156; 63629-8795; 67680-001; 60505-2522; 42185-7038; 63415-0034; 46438-1109
Synonyms Cilostazol | 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinone | OPC 13013 | OPC-13013 | Pletal
Chemical Information
Molecular Formula C20H27N5O2
CAS Registry Number 73963-72-1
SMILES C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haematuria24.07.01.047; 20.02.01.0060.001375%
Haemoglobin13.01.05.018--Not Available
Haemoptysis22.02.03.004; 24.07.01.006; 02.01.02.0060.001375%Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.008--
Haemorrhage subcutaneous24.07.06.010; 23.06.07.002--Not Available
Haemorrhagic disorder24.07.01.021; 01.01.03.004--Not Available
Headache17.14.01.0010.003439%
Hemiparesis17.01.04.0010.001375%
Hepatic function abnormal09.01.02.001--Not Available
Hyperaesthesia17.02.06.004--Not Available
Hypertension24.08.02.0010.002063%
Hyperuricaemia14.09.01.003--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.0020.000359%
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.0330.001375%Not Available
Iron deficiency anaemia14.13.02.001; 01.03.01.002--Not Available
Jaundice09.01.01.004; 01.06.04.004; 23.03.03.030--Not Available
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Long QT syndrome02.03.01.0170.002063%Not Available
Loss of consciousness17.02.04.0040.001375%Not Available
Malaise08.01.01.003--
Melaena24.07.02.013; 07.12.02.004--Not Available
Menopausal symptoms21.02.02.002--Not Available
Mental impairment19.21.02.003; 17.03.03.0020.001375%Not Available
Muscle haemorrhage24.07.01.037; 15.05.03.0170.002063%Not Available
Muscle spasms15.05.03.004--
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